Preliminary Investigation on Antimycotic Synergism of Raw Honey and Essential Oil of Thyme (Thymus vulgaris L.)
|Moussa Ahmed*, Saad Aissat, Abdelmelek Meslem and Noureddine Djebli|
|Pharmacognosy and Api-Phytotherapy Research Laboratory, Mostaganem University, Algeria|
|Corresponding Author :||Dr. Ahmed Moussa
Pharmacognosy and Api-
Phytotherapy Research Laboratory
Mostaganem University, Algeria
Tel: +213 65234059
E-mail: [email protected]
|Received October 10, 2014; Accepted November 19, 2014; Published November 21, 2014|
|Citation: Ahmed M, Aissat S, Meslem A, Djebli N (2014) Preliminary Investigation on Antimycotic Synergism of Raw Honey and Essential Oil of Thyme (Thymus vulgaris L.). Med Aromat Plants 3:177. doi:10.4172/2167-0412.1000177|
|Copyright: © 2014 Ahmed M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
Aims: Several natural products have exhibited synergistic activity against microorganisms. In this study we
investigated the existence of synergistic antifungal effect between Thyme (Thymus vulgaris L.) essential oil and different varieties of raw honey from Algeria.
Methodology: To evaluate antimycotic effects of mixtures of raw honey (RH) and Thymus vulgaris oil (TVO)
using agar disc diffusion assay. The antimycotic capacity was determined against two pathogenic yeasts clinical isolates Candida albicans and Rhodotorula mucilaginosa.
Results: The results indicated that the essential oil of TVO and raw honey are efficient against the tested
yeasts. The diameters of inhibition Zone (DIZ) values were all between 8.26-9.5 mm for the RH and between
8.56-10.3 mm for the TVO. RH and TVO interacted synergistically to inhibit Candida albicans and Rhodotorula mucilaginosa.
Conclusion: These results revealed that combinations of TVO with RH can be used for the development of
potent and novel antifungal agents.