alexa Premature Greying of Hair (Premature Canities): A Concern for Parent and Child
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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Review Article

Premature Greying of Hair (Premature Canities): A Concern for Parent and Child

PK Nigam1* and Pallavi Nigam2

1Department of Dermatology and STD, Pt. J.N.M Medical College, Raipur, India

2Department of Dermatology, BVP Medical College, Pune, India

Corresponding Author:
PK Nigam
Department of Dermatology and STD Pt. J.N.M Medical College, Pune, India
Tel: 917712220944
E-mail: [email protected]

Received date: February 21, 2017; Accepted date: March 04, 2017; Published date: March 11, 2017

Citation: Nigam PK, Nigam P (2017) Premature Greying of Hair (Premature Canities): A Concern for Parent and Child. Pigmentary Disorders 4:261. doi:10.4172/2376-0427.1000260

Copyright: © 2017 Nigam PK, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Hair goes grey with chronological aging. Premature hair greying may have significant adverse effects on the appearance, self-esteem, and socio-cultural acceptance of the affected individual. The exact aetiopathogenetic mechanism causing premature greying is still not clear and much speculative. Premature canities may appear alone as an autosomal dominant trait or it may occur in association with certain other disorders. The genes Pax3 and MITE play an important role in melanocyte stem cell maintenance and differentiation. Defective melanosomal transfer to the cortical keratinocytes or melanin incontinence due to melanocyte degeneration is also believed to contribute to greying. Despite the extensive molecular research being carried out to understand the pathogenesis of canities, treatment options still remain far from satisfactory and no effective therapy is available. Premature greying is a feature in a number of well recognised syndromes. A number of other conditions have also been observed to be associated with premature greying of hair.


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