Premature Thymic Involution and Multiple SclerosisDavid G. Haegert*
Professor, Department of Pathology, McGill University, Canada
- Corresponding Author:
- David Haegert
Duff Building, Room B22
3775 rue University Montreal QC, H3A 2B4, Canada
E-mail: [email protected]
Received date: April 07, 2014; Accepted date: May 23, 2014; Published date: May 30, 2014
Citation: Haegert DG (2014) Premature Thymic Involution and Multiple Sclerosis. J Neurol Neurophysiol 5:207. doi:10.4172/2155-9562.1000207
Copyright: © 2014 Haegert DG. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
It is uncertain as to whether similar or different mechanisms contribute to different subtypes of multiple sclerosis
(MS). A unifying concept proposes that patients with both relapsing-remitting MS (RRMS) and primary progressive
MS (PPMS) have premature thymic involution, which alters peripheral T-cell homeostasis and leads to T-cell
alterations that contribute to the pathogenesis of both MS subtypes.