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Prenatal Pesticide Exposure: Meconium as a Biomarker and Impact on Fetal Weight | OMICS International | Abstract
ISSN: 2161-0525

Journal of Environmental & Analytical Toxicology
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Research Article

Prenatal Pesticide Exposure: Meconium as a Biomarker and Impact on Fetal Weight

Mona AH El-Baz1*, Sahar EM El-Deek1, Ahmed Y Nsar1, Nagwa Abo El-Maali2, Faten F AbdelHafez3 and Ahmed F Amin3
1Department of Medical Biochemistry, Assiut School of Medicine, Assiut University, Egypt
2Department of Analytical Chemistry, Faculty of Science, Assiut University, Egypt
3Women Health Hospital, Assiut School of Medicine, Assiut University, Egypt
Corresponding Author : Mona AH El-Baz
Department of Medical Biochemistry
Assiut School of Medicine, Assiut University, 71515, Egypt
Tel: +201005800409
E-mail: [email protected]
Received December 08, 2014; Accepted January 15, 2015; Published January 20, 2015
Citation: Citation: El-Baz MAH, El-Deek SEM, Nsar AY, El-Maali EA, Abdel Hafez FF, Amin AF (2015) Prenatal Pesticide Exposure: Meconium as a Biomarker and Impact on Fetal Weight. J Environ Anal Toxicol 5:268. doi: 10.4172/2161-0525.1000268
Copyright: ©2015 El-Baz MAH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Prenatal exposure to pesticides can adversely affect fetal health. This study aims to measure levels of some pesticides in meconium obtained from newborns whose mothers were exposed to pesticides, and to identify the effect of maternal exposure to pesticides on neonatal weight. Methods: This is a cross-sectional study. It was carried out on 190 cases (106 exposed and 84 non-exposed to pesticides). Nine pesticides (pretilachlor, DDT, lindane, chloropyrifos, diazinon, malathion, bioallethrin, α cyprmethrin and β cyfluthrin) were detected by Gas Chromatography/ Mass Spectrometry (GC/MS). Results: The frequencies of pesticides detection in the samples were: 54.7%, 57.4%, 50%, 35.8%, 53.7%, 49.5%, 34.7%, 41.1% and 21.5% respectively. Those who reported prenatal exposure to pesticides were four times more likely to work in agricultural work (OR=4.5, 95% CI= 2.1- 9.8). Moreover, those who reported prenatal exposure to pesticides were 1.6 times more likely to have babies with low birth weight (OR=1.59, 95% CI=1.2 - 6.3). Conclusions: Agricultural pregnant workers in our community were significantly more exposed to several types of pesticides and this was associated with impaired fetal growth.

Keywords

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