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Research Article

Preparation and Characterization of a Novel Injectable Hydrogel

Jian-feng Pan, Chang-an Guo, Teng Fei, Wen-shuai Fan, Jia Liu, Shuo Li and Zuo-qin Yan*
Department of Orthopedics, Zhongshan Hospital of Fudan University, Shanghai 200032, China
Corresponding Author : Zuo-qin Yan, MD,PhD
Department of Orthopedics
Zhongshan Hospital of Fudan University
No. 180, Fenglin Road, Xuhui District
Shanghai, 200032, China
Tel: 021-64041990-5488
Fax: 021-64037269
E-mail: [email protected], [email protected]
Received December 27, 2012; Accepted January 27, 2013; Published January 30, 2013
Citation: J, Guo C, Fei T, Fan W, Liu J, et al. (2013) Preparation and Characterization of a Novel Injectable Hydrogel. Adv Genet Eng 2:105. doi:
Copyright: © 2013 Pan J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Injectable hydrogels have emerged as a great candidate in tissue engineering for they can be delivered via a minimally invasive manner. Here, we report an in situ forming hydrogel composited of oxidized dextran (Odex) and modified gelatin. The dynamic gelling process was measured through rheological measurements. The effect of the ratio of Odex and gelatin on gelling time, microstructure, swelling ratio and in vitro degradation of the composite hydrogels were examined. Biological assess was performed through WST-1 Assay by using Synovium-derived Mesenchymal Cells (SMSCs). According to the results, adjustable physicochemical properties can be obtained through simply altering the ratio of Odex and gelatin. Moreover, with the increase of incorporated gelatin, better biocompatibility was shown in the composite hydrogels, which exhibited its potentially high application prospect in the field of cartilage tissue engineering.

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