alexa Preparation and Evaluation of Controlled Release Tablets Containing Mefenamic Acid
ISSN: 2161-1459

Journal of Clinical & Experimental Pharmacology
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Research Article

Preparation and Evaluation of Controlled Release Tablets Containing Mefenamic Acid

Mohammad Usman3, Irshad Ali1, Hafsa Bibi1, Javeid Iqbal2 and Kashif Iqbal3*

1Department of Chemistry, Gomal University, Dera Ismail Khan, KPK, Pakistan

2Faculty of Pharmacy, Hamdard University, Karachi, Pakistan

3Mohi-Ud-Din Islamic Institute of Pharmaceutical Sciences, MIU, Mirpur, AJK

*Corresponding Author:
Kashif Iqbal
Mohi-Ud-Din Islamic Institute of Pharmaceutical Sciences
MIU, Mirpur, AJK
Tel: 0092-333-9959480
E-mail: [email protected]

Received Date: March 16, 2012; Accepted Date: April 19, 2012; Published Date: April 20, 2012

Citation: Usman M, Ali I, Bibi H, Iqbal J, Iqbal K (2012) Preparation and Evaluation of Controlled Release Tablets Containing Mefenamic Acid. Clin Exp Pharmacol 2:107. doi: 10.4172/2161-1459.1000107

Copyright: ©2012 Usman M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



In the present study, Mefenamic acid 200 mg controlled release matrices were prepared by direct compression and in vitro drug dissolution studies were performed to find out the drug release rate and patterns. Methocel was used as rate controlling polymer. Also the effect of several co-excipients was investigated on the drug release rates during in vitro dissolution studies. Polymer Methocel was used as a rate controlling polymer and was formulated with the drug at 4 different D: P ratios. Phosphate buffer pH 7.2 was used as dissolution medium using PharmaTest dissolution apparatus. Several kinetic models were applied to the dissolution profiles to determine the drug release kinetics. Dissolution equivalency evaluation was performed using f2 similarity factor.


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