Preparation and Evaluation of Floating Microspheres of Cefdinir in Treatment of Otitis Media and Respiratory Tract Infections
Anjali Devi N*, Vijendar C, Anil Goud K, Anil Kumar D, Khaja M and Anil A
Department of Pharmaceutics, University College of Pharmaceutical Sciences, Kakatiya University, Warangal 506009, Telangana, India
- *Corresponding Author:
- Anjali Devi N
Department of Pharmaceutics, University
College of Pharmaceutical Sciences
Kakatiya University, Warangal 506009
E-mail: [email protected]
Received Date: March 22, 2016; Accepted Date: May 21, 2016; Published Date: May 26, 2016
Citation: Devi AN, Vijendar C, Goud AK, Kumar AD, Khaja M, et al. (2016) Preparation and Evaluation of Floating Microspheres of Cefdinir in Treatment of Otitis Media and Respiratory Tract Infections. J Pharmacovigilance 4:209. doi: 10.4172/2329-6887.1000209
Copyright: © 2016 Devi AN, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The main objective of the present investigation was to develop gastro retentive (floating) microsphere for Cefdinir. Cefdinir, Third-generation bactericidal cephalosporin antibiotic drugs has been chosen as a model drug in the formulation of floating drug delivery systems. It is a drug of choice in treatment of otitis media, soft tissue infections, and respiratory tract infections, including sinusitis, strep throat, community-acquired pneumonia and acute exacerbations of bronchitis. Three biocompatible polymers like HPMC, Ethyl cellulose and Eudragit were chosen in varying proportions with the drug. F5 formulation with drug: polymer (1:2) show excellent micromeritic properties, percent yield (87.22%), drug entrapment efficiency (92%), percent buoyancy (89%), and highest invitro drug release 98.9% within 12 h. In the stability studies no significant change in drug entrapment release characteristics of the microspheres.