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ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
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Research Article

Preparation, Characterization and Cell Based Delivery of Stavudine Surface Modified Lipid Nanoparticles

Ranjita Shegokar1,2* and Kamalinder K. Singh1

1C.U. Shah College of Pharmacy, S.N.D.T. Women’s University, Santacruz (W), Mumbai 400049, India

2Freie Universität Berlin, Institute of Pharmacy, Department Pharmaceutics, Biopharmaceutics, & NutriCosmetics, Kelchstraße 31, 12169 Berlin, Germany

*Corresponding Author:
Ranjita Shegokar
Freie Universität Berlin, Institute of Pharmacy
Department Pharmaceutics
Biopharmaceutics, & NutriCosmetics
Kelchstraße 31, 12169 Berlin, Germany
Tel: +49-30-83850624
Fax: +49-30- 83850616
E-mail: [email protected]

Received date: March 15, 2012; Accepted date: April 23, 2012; Published date: April 25, 2012

Citation: Shegokar R, Singh KK (2012) Preparation, Characterization and Cell Based Delivery of Stavudine Surface Modified Lipid Nanoparticles. J Nanomed Biotherapeut Discov 2:105. doi:10.4172/2155-983X.1000105

Copyright: © 2012 Shegokar R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Previously it was shown that uncoated lipid nanoparticles of stavudine proved effective in targeting HIV
viral sites in body. Therefore, the main objective of this work was to prepare and characterize surface modified
stavudine entrapped lipid nanoparticles as potential drug delivery system for anti-HIV chemotherapy. The
physical, targeting potential (both in vitro and in vivo) and toxicological evaluation was performed on developed
nanocarriers. The degree of targeting and cellular uptake demonstrated differences among the surface coated
lipid nanoparticles. We found that developed lipid nanoparticles are easy to prepare using high pressure
homogenization, and has excellent stability at room temperature and refrigeration condition. In future, developed surface modified lipid nanoparticles can be evaluated clinically.

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