Preparation of Copper-Doped Hydroxyapatite with Varying x in the Composition Ca10(PO4)6CuxOyHz
- Corresponding Author:
- Flora Imrie
School of Medical Sciences
Institute of Medical Sciences
University of Aberdeen, Foresterhill
Aberdeen, AB25 2ZD, United Kingdom
E-mail: [email protected]
Received date: June 08, 2013; Accepted date: July 23, 2013; Published date: August 23, 2013
Citation: Imrie FE, Skakle JMS, Gibson IR (2013) Preparation of Copper-Doped Hydroxyapatite with Varying x in the Composition Ca10(PO40)6CuxOyHz. Bioceram Dev Appl S1:005. doi:10.4172/2090-5025.S1-005
Copyright: © 2013 Imrie FE, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The pro-angiogenic potential of copper ions could increase the viability of bone forming cells within a bone substitute scaffold, and so hasten healing, by stimulating infiltration of blood vessels into the scaffold. Copper-doped hydroxyapatite with x = 0, 0.5, 0.75 and 1 in the nominal formula Ca10(PO4)6CuxOyHz was prepared by solid state synthesis. Lattice parameters increased as x was increased, consistent with formation of Cu-O species on hydroxyl sites. In FT-IR spectra, the OH stretch (3572 cm-1) and the OH libration (631 cm-1) decreased in intensity as x was increased, and a band at 771-778 cm-1 was assignable to a Cu-O stretch, characteristic of Cu+ bands between 3140 and 3450 cm-1 related to copper-disturbed OH stretching vibrations. In UV visible spectra, bands between 400 and 800 nm were assignable to d-d transitions of Cu2+. Therefore we propose that Cu is present in these materials both as Cu+ and Cu2+.