alexa
Reach Us +1 218 451 2974
Present and Future RNA-based Approaches to Medical Genomics | OMICS International | Abstract
ISSN: 2472-128X

Journal of Clinical & Medical Genomics
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)
All submissions of the EM system will be redirected to Online Manuscript Submission System. Authors are requested to submit articles directly to Online Manuscript Submission System of respective journal.

Review Article

Present and Future RNA-based Approaches to Medical Genomics

Robert Penchovsky*

Department of Genetics, Faculty of Biology, Sofia University “St. KlimentOhridski”, 8 Dragan TzankovBlvd., 1164 Sofia, Bulgaria

*Corresponding Author:
Robert Penchovsky
Department of Genetics, Faculty of Biology
Sofia University “St. KlimentOhridski”
8 Dragan TzankovBlvd., 1164 Sofia, Bulgaria
Tel: +35928167340
E-mail: [email protected]

Received date: July 29, 2013; Accepted date: October 08, 2013; Published date: October 18, 2013

Citation: Penchovsky R (2013) Present and Future RNA-based Approaches to Medical Genomics. Int J Genomic Med 1:110. doi: 10.4172/2332-0672.1000110

Copyright: © 2013 Penchovsky R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Nucleic acids-based technology is emerging as a valuable field that integrates research from science and technology to create novel nanodevices and nanostructures with various applicationsin modern nanotechnology. Nowadays, applicationsof RNA-based technologyare employed in biomedical and pharmaceutical research, biosensoring, nanopharmaceutics and others. It has been proven that RNA isa very suitable medium for selfassembly of diverse nanostructures, catalytic nanodevices and cell delivery systems.At the same time, genomics is becoming increasingly valuable for modern medicine due to the advancements made by second generation sequencing technologies. In this review, I discuss various applications of designer ribozymes and diverse RNAbased approaches to medical genomics. The areas discussed include RNA-based approaches for molecular sensoring and diagnostics, antibacterial drug discovery, exogenous control of gene expression, and gene silencing. These approaches havebecomepossible due to the advancement of various methods for engineering functional RNAsas well asthe discoveries made in RNA biology. Furthermore, different RNA-based antisense technologies are reviewed together with methods for nucleic acid delivery to the cell. The research that has been done so far in the field of RNA engineering hasa far-reaching impact on medical genomics, which isthe main focus of this review.

Keywords

Leave Your Message 24x7
Top