Present and Future RNA-based Approaches to Medical GenomicsRobert Penchovsky*
Department of Genetics, Faculty of Biology, Sofia University “St. KlimentOhridski”, 8 Dragan TzankovBlvd., 1164 Sofia, Bulgaria
- *Corresponding Author:
- Robert Penchovsky
Department of Genetics, Faculty of Biology
Sofia University “St. KlimentOhridski”
8 Dragan TzankovBlvd., 1164 Sofia, Bulgaria
E-mail: [email protected]
Received date: July 29, 2013; Accepted date: October 08, 2013; Published date: October 18, 2013
Citation: Penchovsky R (2013) Present and Future RNA-based Approaches to Medical Genomics. Int J Genomic Med 1:110. doi: 10.4172/2332-0672.1000110
Copyright: © 2013 Penchovsky R. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Nucleic acids-based technology is emerging as a valuable field that integrates research from science and technology to create novel nanodevices and nanostructures with various applicationsin modern nanotechnology. Nowadays, applicationsof RNA-based technologyare employed in biomedical and pharmaceutical research, biosensoring, nanopharmaceutics and others. It has been proven that RNA isa very suitable medium for selfassembly of diverse nanostructures, catalytic nanodevices and cell delivery systems.At the same time, genomics is becoming increasingly valuable for modern medicine due to the advancements made by second generation sequencing technologies. In this review, I discuss various applications of designer ribozymes and diverse RNAbased approaches to medical genomics. The areas discussed include RNA-based approaches for molecular sensoring and diagnostics, antibacterial drug discovery, exogenous control of gene expression, and gene silencing. These approaches havebecomepossible due to the advancement of various methods for engineering functional RNAsas well asthe discoveries made in RNA biology. Furthermore, different RNA-based antisense technologies are reviewed together with methods for nucleic acid delivery to the cell. The research that has been done so far in the field of RNA engineering hasa far-reaching impact on medical genomics, which isthe main focus of this review.