alexa Pressures of Injection in a Cadaver Model of Peripheral Nerve Blockade | OMICS International | Abstract
ISSN: 2155-6148

Journal of Anesthesia & Clinical Research
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Research Article

Pressures of Injection in a Cadaver Model of Peripheral Nerve Blockade

Scott Ross1, Kelly Edwards2, Kate Lane3, Paul E Bigeleisein4 and Steven L Orebaugh1*

1Department of Anesthesiology, University of Pittsburgh School of Medicine, USA

2Biomedical Engineering Student, University of Pittsburgh, USA

3Department of Pathology, University of Pittsburgh School of Medicine, USA

4Department of Anesthesiology, University of Maryland School of Medicine, USA

*Corresponding Author:
Steven L Orebaugh
Department of Anesthesiology
University of Pittsburgh School of Medicine
UPMC-Southside/Mercy Anesthesia; 2000 Mary Street Pittsburgh PA 15203, USA
Tel: 412-488-5799
Fax: 412-488-5796
E-mail: [email protected]

Received date: July 25, 2014; Accepted date: October 15, 2014; Published date: October 20, 2014

Citation: Ross S, Edwards K, Lane K, Bigeleisein PE, Orebaugh SL (2014) Pressures of Injection in a Cadaver Model of Peripheral Nerve Blockade. J Anesth Clin Res 5:445. doi: 10.4172/2155-6148.1000445

Copyright: © 2014 Ross S, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Objective: Pressure monitoring during injection has been suggested to help detect intrafascicle needle placement. We performed injections, guided by ultrasound, into the cervical nerve roots, peripheral nerves of the extremities, and perineural soft tissues of an unpreserved cadaver. We hypothesized that needle tip placement into these three sites would yield significantly different injection pressures, and that histologic analysis would allow comparison of intrafascicle vs. extrafascicle pressures of injection.

Methods: Injections of 5 ml ropivacaine 0.5% were conducted at cervical roots (n=4), peripheral nerves of the extremities (n=10) and perineural soft tissues (n=9), at constant rate while monitoring pressure. Dye was instilled at the termination of the injection for histologic determination of needle position. Peak pressures and time to peak pressures, were compared for these three sets of injections. After microscopic examination, all intrafascicular and extrafascicular pressures were grouped together and compared.

Results: Mean peak injection pressures for the three groups were found to be significantly different, (p=0.0002). At histological examination, four of 10 peripheral nerve injections resulted in deposition of dye within fascicles, while six of 10 did not. Mean peak intrafascicle injection pressures were significantly higher than those for injections outside of fascicles (p<0.0001). Time to peak injection pressure was not different for these two groups.

Discussion: Comparison of intrafascicle versus extrafascicle injections showed a clear delineation of peak pressures into two ranges. This adds to prior evidence, from both human cadavers and live animals, showing that intrafascicle injections generate high pressures, whether conducted in nerve roots or peripherally.


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