Reach Us +1 218 451 2974
Presynaptic Neuromuscular Transmission Defect in Anti-GQ1b IgG Antibody-Related Disorders | OMICS International | Abstract
ISSN: 2155-9562

Journal of Neurology & Neurophysiology
Open Access

Like us on:

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Presynaptic Neuromuscular Transmission Defect in Anti-GQ1b IgG Antibody-Related Disorders

YL Lo1*, A Seah1, LL Lim1, TH Leoh2, YF Dan2, S Fook-Chong3 and P Ratnagopal1

1Department of Neurology, National Neuroscience Institute, Singapore General Hospital, Singapore

2Department of Neurology, Singapore General Hospital, Singapore

3Department of Clinical Research, Singapore General Hospital, Singapore

Corresponding Author:
Dr. A/Prof Lo
Department of Neurology
National Neuroscience Institute
Singapore General Hospital, Outram Road
Singapore 169608, Singapore
Tel: 65 63265003
Fax: 65 62203321
E-mail: [email protected]

Received date: November 25, 2010; Accepted date: April 06, 2011; Published date: April 08, 2011

Citation: Shah D, Nandakumar S, Jaishankar GB, Chilakala S, Wang K, et al. (2011) Pre-Term Exposure Patterns in Neonatal Intensive Care Unit Alters Immunological Outcome in Neonates. J Aller Ther 2:106. doi:10.4172/2155-9562.1000111

Copyright: ©2011 Lo YL, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, hich permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Background: In vitro studies of Miller Fisher syndrome (MFS) have demonstrated anti-GQ1b IgG antibodymediated presynaptic damage at the neuromuscular junction. Previous studies have provided electrophysiological evidence of presynaptic neuromuscular transmission defect in MFS in anti-GQ1b positive patients, which persisted up to 3 months from initial presentation. Methods and results: In this study, we show that incremental responses were significantly greater in antibodypositive MFS and Bickerstaff's brainstem encephalitis, compared with antibody-negative Guillain-Barre and MFS variants. These responses return to normality by 6 months, in tandem with clinical recovery. Conclusions: The findings have pertinent implications on developing management strategies of these conditions.