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Retention in Differentiated Care: Multiple Measures Analysis for a Decentralized HIV Care and Treatment Program in North Central Nigeria | OMICS International | Abstract
ISSN 2155-6113

Journal of AIDS & Clinical Research
Open Access

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Research Article

Retention in Differentiated Care: Multiple Measures Analysis for a Decentralized HIV Care and Treatment Program in North Central Nigeria

Patricia A Agaba1, Becky L Genberg2, Atiene S Sagay1, Oche O Agbaji1, Seema T Meloni3, Nancin Y Dadem4, Grace O Kolawole4, Prosper Okonkwo5, Phyllis J Kanki3 and Norma C Ware6,7*
1Faculty of Medical Sciences, University of Jos, Nigeria
2Bloomberg School of Public Health, Baltimore, MD, Johns Hopkins University, USA
3Harvard TH Chan School of Public Health, , Boston, MA, USA
4APIN Centre, Jos University Teaching Hospital, , Jos, Nigeria
5AIDS Prevention Initiative Nigeria Lte, , Abuja, Nigeria
6Harvard Medical School, , Boston MA, USA
7Brigham & Women’s Hospital,, , Boston, MA, USA
*Corresponding Author: Norma C Ware, Department of Global Health and Social Medicine, Harvard Medical School, 641 Huntington Ave, Boston, MA 02115, USA, Tel: 1 617 432-2554, Fax: 1 617 432-2565, Email: [email protected]

Received Date: Jan 19, 2018 / Accepted Date: Feb 06, 2018 / Published Date: Feb 13, 2018

Citation: Agaba PA, Genberg BL, Sagay AS, Agbaji OO, Meloni ST, et al. (2018) Retention in Differentiated Care: Multiple Measures Analysis for a Decentralized HIV Care and Treatment Program in North Central Nigeria. J AIDS Clin Res 9: 756.DOI: 10.4172/2155-6113.1000756

Copyright: © 2018 Agaba PA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Differentiated care refers collectively to flexible service models designed to meet the differing needs of HIV-infected persons in resource-scarce settings. Decentralization is one such service model. Retention is a key indicator for monitoring the success of HIV treatment and care programs. We used multiple measures to compare retention in a cohort of patients receiving HIV care at “hub” (central) and “spoke” (decentralized) sites in a large public HIV treatment program in north central Nigeria.
Methods: This retrospective cohort study utilized longitudinal program data representing central and decentralized levels of care in the Plateau State Decentralization Initiative, north central Nigeria. We examined retention with patientlevel (retention at fixed times, loss-to-follow-up [LTFU]) and visit-level (gaps-in-care, visit constancy) measures. Regression models with generalized estimating equations (GEE) were used to estimate the effect of decentralization on visit-level measures. Patient-level measures were examined using survival methods with Cox regression models, controlling for baseline variables.
Results: Of 15,650 patients, 43% were enrolled at the hub. Median time in care was 3.1 years. Hub patients were less likely to be LTFU (adjusted hazard ratio (AHR)=0.91, 95% CI: 0.85-0.97), compared to spoke patients. Visit constancy was lower at the hub (-4.5%, 95% CI: -3.5,-5.5), where gaps in care were also more likely to occur (adjusted odds ratio=1.95, 95% CI: 1.83-2.08).
Conclusion: Decentralized sites demonstrated better retention outcomes using visit-level measures, while the hub achieved better retention outcomes using patient-level measures. Retention estimates produced by incorporating multiple measures showed substantial variation, confirming the influence of measurement strategies on the results of retention research. Future studies of retention in HIV care in sub-Saharan Africa will be well-served by including multiple measures.