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ISSN: 2155-6121

Journal of Allergy & Therapy
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Research Article

Pre-Term Exposure Patterns in Neonatal Intensive Care Unit Alters Immunological Outcome in Neonates

Darshan Shah2,5, Subhadra Nandakumar1,3,5, Gayatri Bala Jaishankar2, Sandeep Chilakala2, Kesheng Wang4 and Uday Kumaraguru1*

1Department of Microbiology, Quillen College of Medicine, East Tennessee State University, Johnson City, TN-37614, USA

2Department of Pediatrics, Quillen College of Medicine, East Tennessee State University, Johnson City, TN-37614, USA

3National Center for HIV, Hepatitis, STD and TB prevention, MLB, DTBE, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA

4Department of Biostatistics and Epidemiology, College of Public Health, East Tennessee State University, Johnson City, TN-37614, USA

5Equal contribution

*Corresponding Author:
Uday Kumaraguru
Department of Microbiology
Quillen College of Medicine
East Tennessee State University
Johnson City, TN-37614
Tel:423-439-6227
Fax: 423-439-8044
E-mail: [email protected]

Received date: April 17, 2012; Accepted date: May 29, 2012; Published date: May 31, 2012

Citation: Shah D, Nandakumar S, Jaishankar GB, Chilakala S, Wang K, et al. (2011) Pre-Term Exposure Patterns in Neonatal Intensive Care Unit Alters Immunological Outcome in Neonates. J Aller Ther 2:106. doi: 10.4172/2155-6121.1000106

Copyright: © 2011 Shah D, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Advances in technology have lowered the limits of viability in premature births to 24 weeks of gestation. This brought forth a new population of children, who are born 3-4 months early and spent considerable amounts of time in neonatal intensive care unit (NICU), instead of sterile environment of mother’s womb. Besides, other problems associated with prematurity, these children often undergo invasive procedures resulting in mucosal inflammation and/ or injury by feeding tubes, endotracheal tubes, and prolonged IV catheter. To test whether “ex-preemie-infants” were different than “term-infants” with regard to their immunity, preterm infants (< 32 weeks) and term infants (control) at the corrected age of 9-12 months were analyzed for their resting and stimulated immune responses. Preterm infants had a significant Th1 skewed response, higher number of activated and functionally competent T cells compared to term infants. The critical role of neonatal environmental exposure on immune system development is imminent; nevertheless detailed mechanistic studies on pathways are warranted.

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