alexa Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats
ISSN: 2161-0495

Journal of Clinical Toxicology
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats

Houman Alimoradi1, Anita Barzegar-Fallah2, Sanaz Mohammadi-Rick3, Firouzeh Asadi2, Bahram Delfan4 and Ahmad Reza Dehpour2*

1Department of Pharmacology and Toxicology, Faculty of Pharmacy, Toxicology Research Center, Jundishapur University of Medical Sciences, Ahvaz, Iran

2Pharmacology Department, School of Medicine, Tehran University of Medical Sciences, Tehran, Iran

3Islamic Azad University of Pharmaceutical Sciences, Tehran, Iran

4Department of pharmacology, Faculty of Medicine, Lorestan University Of Medical Sciences, Khorramabad, Iran

*Corresponding Author:
Ahmad Reza Dehpour
Pharmacology Department, School of Medicine
Tehran University of Medical Sciences, Tehran, Iran
Tel: 98 2188 973 652
Fax: 98 2166 402 569
E-mail: [email protected]

Received date: February 03, 2012; Accepted date: March 15, 2012; Published date: March 18, 2012

Citation: Alimoradi H, Barzegar-Fallah A, Mohammadi-Rick S, Asadi F, Delfan B, et al. (2012) Pretreatment of CAV Combination Chemotherapy with Tropisetron Shows Less Cardio and Neurotoxicity Side Effects in Rats. J Clinic Toxicol S6:001. doi: 10.4172/2161-0495.S6-001

Copyright: © 2012 Alimoradi H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Tropisetron, a 5-HT3 antagonist receptor, is commonly used for the prevention of emesis following chemotherapy. Lines of evidence point to the anti-inflammatory and immune modulatory properties of tropisetron. The current study aims to investigate whether tropisetron is able to prevent the cardiotoxicity and neurotoxicity induced by doxorubicin (DOX) and vincristine besides its anti emetic effect in a co-administration protocol, since this combination therapy is widely used in various combination chemotherapy regimens. To investigate these effects, intraperitoneal co-administration of doxorubicin and vincristine in CAV combination therapy (Cyclophosphamide, Adriamycin and Vincristine) was used to induce neuro and cardiotoxicity and in treated group tropisetron was injected 1 h prior to combination therapy. General conditions, mortality rate and body weight were measured during the experiment. Moreover, assessment of biomarkers of cardiac injury, ECG (Electrocardiogram) parameters and papillary muscle contractility force were done for evaluating of cardio protective effects of tropisetron. Similarly, hot plate, open field and nerve conduction velocity tests were used for investigation of neuroprotective effects of tropisetron against the side effects of this combination. The findings in the present study indicated that tropisetron pretreatment led to significant decrease in levels of serum cardiac damage biomarkers, electrocardiographic changes and toxicities associated with this combination chemotherapy. Also, it improved behavioral and electrophysiological scores, papillary muscle contractility force and rats’ general conditions. Consequently, it is suggested that tropisetron is beneficial for the prevention of cardiotoxicity and neurotoxicity and could be considered as a new indication for alleviation of side effects of these drugs in combination therapies.

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri, Food, Aqua and Veterinary Science Journals

Dr. Krish

[email protected]

1-702-714-7001 Extn: 9040

Clinical and Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemical Engineering and Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001 Extn: 9040

Earth & Environmental Sciences

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

General Science and Health care Journals

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics and Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001 Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Informatics Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Material Sciences Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Mathematics and Physics Journals

Jim Willison

[email protected]

1-702-714-7001 Extn: 9042

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001 Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

John Behannon

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001 Extn: 9042

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords