Prevalence and Clinical Significance of Mycoplasma genitalium in Gynecologic PatientsOluwatosin Goje1*, Jessian L Munoz1, Frederick S Nolte2 and David E Soper3
- Corresponding Author:
- Oluwatosin Goje
Obstetrics, Gynecology and Women's Health Institute
Cleveland Clinic, Desk A81, 9500 Euclid Avenue
Cleveland, OH 44195, USA
E-mail: [email protected]
Received date: May 11, 2017; Accepted date: May 17, 2017; Published date: May 24, 2017
Citation: Goje O, Munoz JL, Nolte FS, Soper DE (2017) Prevalence and Clinical Significance of Mycoplasma genitalium in Gynecologic Patients. J AIDS Clin Res 8:694. doi:10.4172/2155-6113.1000694
Copyright: © 2017 Goje O, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Mycoplasma genitalium has been recognized as a cause of male urethritis, and there is now evidence suggesting it causes cervicitis and pelvic inflammatory disease (PID) in women. Methods: Prevalence, risk factors and co-infections with other sexually transmitted pathogens were collected in a cross-sectional study looking at 400 women at the gynecologic clinics of a university medical center in the United States. Bacterial vaginosis and trichomoniasis were diagnosed using Amsel’s criteria, gram stain and trichomonas culture respectively. Cervicitis and PID were clinically diagnosed. After testing for Chlamydia trachomatis and Neisseria gonorrhoeae, the residual cervical swab transport medium (Gen-Probe/Hologic®) was stored at -70°C. Stored samples were later analyzed for M. genitalium by a research use only transcription-mediated amplification assay using procedures similar to those established for APTIMA Combo2 assay for C. trachomatis and N. gonorrhoeae (Gen-Probe/Hologic®). Results: The overall prevalence of infection with C. trachomatis, N. gonorrhoeae, T. vaginalis and M. genitalium was found to be 7.8%, 1.8%, 10.43% and 8.9%, respectively. Prevalence of M. genitalium was comparable to that of C. trachomatis and greater than the prevalence of N. gonorrhoeae. Univariate analysis of M. genitalium status showed that participants with lower condom use had an increased probability of M. genitalium (p=0.037). Conclusion: Prevalence of M. genitalium was comparable to C. trachomatis in our study, but more research is needed to clarify pathogenicity.