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ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Prevalence of Genotypes and Sub-Genotypes of the Hepatitis B Virus in a Population of the Brazilian Amazon Region (Para State)

Simone Regina Souza da Silva Conde1,2, Luiz Marcelo Pinheiro3 , José Alexandre Rodrigues de Lemos3 , Samia Demachki1 , Marialva Thereza de Araújo1 , Manoel do Carmo Pereira Soares4 , Heloisa Marceliano Nunes4 , Ricardo Ishak1 and Antonio Carlos Rosário Vallinoto1 *

1 Universidade Federal do Pará, Instituto de Ciências Biológicas, Laboratório de Virologia, Belém, Pará, Brazil

2 Fundação Santa Casa de Misericórdia do Pará, Belém, Pará, Brazil

3 Fundação HEMOPA, Laboratório de Biologia Molecular, Belém, Pará, Brazil

4 Instituto Evandro Chagas, Ananindeua, Pará, Brazil

*Corresponding Author:
Antonio Carlos R Vallinoto
Universidade Federal do Pará
Instituto de Ciências Biológicas
Laboratório de Virologia, Belém, Pará, Brazil
E-mail:[email protected]

Received Date: September 02, 2013; Accepted Date: September 18, 2013; Published Date: September 20, 2013

Citation: da Silva Conde SRS, Pinheiro LM, de Lemos JAR, Demachki S, de Araújo MT, et al. (2013) Prevalence of Genotypes and Sub-Genotypes of the Hepatitis B Virus in a Population of the Brazilian Amazon Region (Pará State). J Antivir Antiretrovir 5:108-112. doi: 10.4172/jaa.1000072

Copyright: © 2013 da Silva Conde SRS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Objectives: The present study identified the prevalent hepatitis B virus (HBV) genotypes and subtypes in patients from the Brazilian state of Pará.
Materials: A sample of 40 patients infected with HBV was selected from a special facility in Belém between January, 2007, and December, 2008. Clinical, biochemical, serological, virological and pathological variables were used to classify patients as inactive carriers and those with chronic hepatitis, either with or without cirrhosis. Serological tests were performed using enzyme immunoassays and viral DNA sequences and the viral load were assessed using PCR. The HBV genotypes were identified through the sequencing of the S region.
Results: All but two of the patients sequenced were genotype A, of which, 92% were A1 and 8% A2. The other two patients were genotype D. The A1 samples were either subtype ayw1 or adw2, while the A2 and D subjects were adw2 and ayw3, respectively. The prevalence of genotype A was 90.5% in group A and 100% in group B.
Conclusion: No association was found between genotype and the clinical outcomes of the HBV infection.

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