Prevalence of Glaucomatous Disease in Young Chinese Adults: A Pilot Study
|Christopher S. Sáles1*, Milica Margeta1, Lydia Hsu1, Teresa Fu1, Janet Y. Tsui2, Young H. Kwon2, Vicki Chan3, Simon Law3, Malik Y. Kahook4, Amy Fang5, Michael Kass5, Nermin Girgis6, Teresa Chen6, James C. Tsai7, Robert Feldman8, Brian Francis9, Shan C. Lin10 and Kuldev Singh1|
|1Byers Eye Institute, Department of Ophthalmology, Stanford University, USA|
|2Department of Ophthalmology and Visual Sciences, University of Iowa, USA|
|3Jules Stein Eye Institute, University of California, Los Angeles, USA|
|4Department of Ophthalmology, University of Colorado, USA|
|5Department of Ophthalmology and Visual Sciences, Washington University, USA|
|6Massachusetts Eye and Ear Infirmary, Harvard Medical School, USA|
|7Department of Ophthalmology and Visual Sciences, Yale University, USA|
|8Department of Ophthalmology and Visual Sciences, University of Texas, Houston, USA|
|9University of Southern California Eye Institute, USA|
|10Department of Ophthalmology, University of California, San Francisco, USA|
|Corresponding Author :||Christopher S. Sáles
Byers Eye Institute at Stanford
2452 Watson Court, Palo Alto, CA 94303, USA
E-mail: [email protected]
|Received January 26, 2014; Accepted March 27, 2014; Published April 03, 2014|
|Citation: Sales CS, Margeta M, Hsu L, Fu T, Tsui JY, et al. (2014) Prevalence of Glaucomatous Disease in Young Chinese Adults: A Pilot Study. J Clin Exp Ophthalmol 5:331. doi: 10.4172/2155-9570.1000331|
|Copyright: © 2014 Sales CS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.|
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Purpose: To estimate the prevalence of glaucomatous disease in a pilot study of young adults with Chinese ancestry.
Methods: 164 adults residing in the United States (US) between 20 and 40 years of age inclusively, who selfidentified as being born to two ethnically Chinese parents, were prospectively recruited at nine university and medical center campuses in the US without disclosing the study's purpose. All subjects completed a standardized, closed-ended questionnaire detailing their genealogy and ocular history, followed by a comprehensive ophthalmic examination, including measurement of intraocular pressure (IOP), central corneal thickness (CCT), and axial length. Participants suspected of having glaucoma based on family history, optic nerve appearance, or IOP also underwent static automated white on white threshold perimetry. Main outcome measures included the prevalence of glaucomatous appearing optic nerves and visual fields as well as associated clinical parameters, including myopia, tilted optic nerves, and peripapillary atrophy. All comparisons were performed using the Student's T, Mann-Whitney U, Pearson's χ2, and Fisher's exact tests.
Results: Nine subjects (5.5%) were observed to have optic nerve appearance and visual field defects suggestive of glaucomatous disease. There was no statistically significant association between this cluster of findings and any other measured clinical parameter.
Conclusions: Young adult individuals of Chinese ancestry may be at substantial risk for glaucomatous disease. Given the cross sectional nature of this study, longitudinal follow-up of participants deemed to be suspicious for glaucoma will be necessary to ascertain whether or not they demonstrate a progressive course consistent with glaucomatous disease.