alexa Prevalence of Hypocalcemia and Its Potential Value as a
ISSN: 2329-891X

Journal of Tropical Diseases & Public Health
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Research Article

Prevalence of Hypocalcemia and Its Potential Value as a Biochemical Marker in Patients with Severe Dengue Infection

Madura Adikari1*, Charith Perera2, Mihika Fernando2, Mark Loeb4, Sunil Premawansa3, Dharshan de Silva2 and Gayani Premawansa1

1Colombo North Teaching Hospital, Ragama, Sri Lanka

2Genetech Research Institute- Colombo, Sri Lanka

3Faculty of Science, University of Colombo, Sri Lanka

4Department of Pathology & Molecular Medicine, Faculty of Health Sciences, McMaster University, Ontario, Canada

*Corresponding Author:
Madura Adikari
Colombo North Teaching Hospital
Ragama, Sri Lanka
Tel: 9471980799
E-mail: [email protected]

Received Date: October 31, 2015 Accepted Date: November 28, 2015 Published Date: December 05, 2015

Citation: Adikari M, Perera C, Fernando M, Loeb M Premawansa S, et al. (2015) Prevalence of Hypocalcemia and Its Potential Value as a Biochemical Marker in Patients with Severe Dengue Infection. J Trop Dis 4:188. doi:10.4172/2329-891X.1000188

Copyright: © 2015 Ayuka F, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Background: Dengue infection is a major public health problem in tropical and subtropical countries including Sri Lanka, leading to significant morbidity and mortality. In severe dengue infection, plasma leakage is observed leading to numerous biochemical derangements including hypocalcemia. We studied the prevalence of hypocalcemia in a population of patients with severe dengue infection.

Methods: A prospective follow up study was conducted in a tertiary care centre in Sri Lanka throughout a one year period. World health organization 2009 criteria were used to diagnose the patients with severe dengue infection. All the patients with severe dengue infection were analyzed with serum ionized calcium during the first 24 hours of onset of the severe dengue clinical criteria.

Results: From the total population of 61 with severe dengue infection, 42(68.8%) were males and 19(31.2%) were females. Mean age of the population was 28.8 years. Among the 61 patients 52(85%) showed hypocalcemia during the first 24 hours of onset of severe dengue infection. Mean ionized calcium level of the population was 0.96 mmol/L, range being 0.53-1.48 mmol/L.

Conclusion: Serum ionized calcium level was significantly reduced in majority of patients with severe dengue infection within the first 24 hours of the onset of severe dengue clinical criteria. Value of serum ionized calcium as a biochemical marker to detect severe dengue infection early should be further explored with large scale studies.


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