Prevalence of Occult Hepatitis B Infection among HIV Infected Patients at an Innercity Clinic
Rajat Nog*, Kumara Singaravelu and Sharon Mannheimer
Columbia University Medical Center affiliation at Harlem Hospital Center Manchester, CT, USA
- *Corresponding Author:
- Rajat Nog
Columbia University Medical Center affiliation at
Harlem Hospital Center Manchester, CT, USA
E-mail: [email protected]
Received Date: June 12, 2013; Accepted Date: October 11, 2013; Published Date: October 16, 2013
Citation: Nog R, Singaravelu K, Mannheimer S (2013) Prevalence of Occult Hepatitis B Infection among HIV Infected Patients at an Innercity Clinic. J AIDS Clin Res 4:252. doi:10.4172/2155-6113.1000252
Copyright: © 2013 Nog R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Considering higher morbidity and mortality associated with HIV/HBV coinfected patients compared to monoinfected patients, it is imperative to determine the prevalence of occult HBV (OHB) infection, in such population.630 unique HIV-infected patients, during the defined study period, were screened for evidence of occult HBV infection serology. 82 patients (13%) were found to have evidence suggestive of OHB infection of which 57 had HBV DNA testing available and comprised the final study population. Data on demographic variables, Hepatitis C antibody status, antiretroviral therapy (ARV), CD4 count and HIV viral load was also collected. Among the final study population, 7% (n=4) patients met the OHB definition. All 4 (100%) with OHB had HIV RNA levels > 50 copies/ml. OHB was found in 4 (22%) of 18 patients not on ARV, but in none of 39 patients on ARV (p=0.007). All patients on ARV were on a regimen with anti HBV activity. 75% of patients with OHB tested positive for HCV compared to 47% in isolated anti HBc positive but HBV DNA negative population (p= 0.58). With an OHB prevalence of 7% in our community clinic, clinicians should have a high index of suspicion for OHB among HIV patients whose hepatitis panel is positive only for anti HBc only and start them on HAART regimen containing ARVs with anti-HBV activity.