alexa Prevalence of the Triple-Negative Phenotype in Mexican Patients with Breast Cancer Treated in Private Practice | OMICS International
ISSN: 2167-0420

Journal of Womens Health Care
Open Access

OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Prevalence of the Triple-Negative Phenotype in Mexican Patients with Breast Cancer Treated in Private Practice

Ana Olivia Cortes-Flores1, Gilberto Morgan-Villela1, Jorge Jiménez-Tornero1, Carlos Zuloaga-Fernández del Valle1, Guillermo Juárez- López1, Clotilde Fuentes-Orozco2, Michel Dassaejv Macías-Amezcua2, Rodrigo Ville-Benavides1, Ernesto Alejandro Juárez-Uzeta1 and Alejandro González-Ojeda2*

1ONKOS Oncology Unit, Guadalajara, Jalisco, México

2Research Unit in Clinical Epidemiology, Specialties Hospital of the Western Medical Center, Medical Unit of High Specialty, Mexican Institute of Social Security, Guadalajara, Jalisco, Monaco

*Corresponding Author:
Alejandro González-Ojeda
Research Unit in Clinical Epidemiology
Western Medical Center, Avenida Belisario Domínguez 1000
Colonia Independencia, CP 44340
Guadalajara, Jalisco, Monaco
Tel: 523338485410
Fax: +5233384854213
E-mail: [email protected]

Received date: May 12, 2014; Accepted date: June 27, 2014; Published date: July 02, 2014

Citation: Cortes-Flores AO, Morgan-Villela G, Jiménez-Tornero J, del Valle CZF, Juárez-López G, et al. (2014) Prevalence of the Triple-Negative Phenotype in Mexican Patients with Breast Cancer Treated in Private Practice. J Women’s Health Care 3:170. doi:10.4172/2167-0420.1000170

Copyright: © 2014 Cortes-Flores AO, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Background: Identifying the biological profile of breast cancer is fundamental to predict the response to various treatments and for prognosis. The aim of this study was to determine the triple-negative breast cancer prevalence in patients treated in private practice in Mexico.
Methods: The study was performed using Mexican patients older than 18 years and had a histopathological diagnosis of breast adenocarcinoma and immunohistochemical studies for estrogen, progesterone, and HER2/Neu receptors, according to validated standards.
Results: A total of 1,989 patients with a mean age of 52.9 ± 13.4 (23–93) years and a tumor size of 2.72 ± 1.12 cm were evaluated. The TNBC biological subtype was observed in 17.3%, HER2/Neu overexpression in 22.6%, and the presence of positive hormonal receptors (estrogen and/or progesterone) in 60.1% of the cases. An association was found between the TNBC type and the degree of differentiation (P<0.01), p53 overexpression (P<0.01, OR=1.84, 95% CI 1.35–2.52), proliferation index (P<0.01, OR=1.83, 95% CI 1.44–2.34), and tumor size (P<0.01). TNBC patients were younger (P<0.01) and lymph node involvement was more common in these patients (P<0.01, OR=4.57, 95% CI 3.53–5.90).
Conclusions: TNBC is a highly aggressive tumor with a lower prevalence in women treated in private practice than in patients treated through the Seguro Popular, probably as a consequence of faster detection and opportune treatment.

Keywords

Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

Agri & Aquaculture Journals

Dr. Krish

[email protected]

1-702-714-7001Extn: 9040

Biochemistry Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Business & Management Journals

Ronald

[email protected]

1-702-714-7001Extn: 9042

Chemistry Journals

Gabriel Shaw

[email protected]

1-702-714-7001Extn: 9040

Clinical Journals

Datta A

[email protected]

1-702-714-7001Extn: 9037

Engineering Journals

James Franklin

[email protected]

1-702-714-7001Extn: 9042

Food & Nutrition Journals

Katie Wilson

[email protected]

1-702-714-7001Extn: 9042

General Science

Andrea Jason

[email protected]

1-702-714-7001Extn: 9043

Genetics & Molecular Biology Journals

Anna Melissa

[email protected]

1-702-714-7001Extn: 9006

Immunology & Microbiology Journals

David Gorantl

[email protected]

1-702-714-7001Extn: 9014

Materials Science Journals

Rachle Green

[email protected]

1-702-714-7001Extn: 9039

Nursing & Health Care Journals

Stephanie Skinner

[email protected]

1-702-714-7001Extn: 9039

Medical Journals

Nimmi Anna

[email protected]

1-702-714-7001Extn: 9038

Neuroscience & Psychology Journals

Nathan T

[email protected]

1-702-714-7001Extn: 9041

Pharmaceutical Sciences Journals

Ann Jose

[email protected]

1-702-714-7001Extn: 9007

Social & Political Science Journals

Steve Harry

[email protected]

1-702-714-7001Extn: 9042

 
© 2008- 2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version