alexa Prevalence of Transmitted HIV-1 Drug Resistance (TDR) Associated Mutations and Predicted Drug Sensitivity in Newly Diagnosed HIV-1 Patient Cohort in a Western New York, 2005-2011 | Abstract
ISSN: 1948-5964

Journal of Antivirals & Antiretrovirals
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Research Article

Prevalence of Transmitted HIV-1 Drug Resistance (TDR) Associated Mutations and Predicted Drug Sensitivity in Newly Diagnosed HIV-1 Patient Cohort in a Western New York, 2005-2011

Lili Dai1,3, Supriya D Mahajan3, Donald L Sykes3, Alyssa Shon2, Stanley A Schwartz3, Ning Li1, Hao Wu1* and Chiu-Bin Hsiao2

1 Center for Infectious Diseases, Beijing You’an Hospital, Capital Medical University, China

2 Department of Medicine, Division of Infectious Diseases, State University of New York at Buffalo, USA

3 Department of Medicine, Division of Allergy, Immunology, and Rheumatology, State University of New York at Buffalo, USA

*Corresponding Author:
Hao Wu
Director of Center for Infectious Diseases
Beijing You’an Hospital, Capital Medical University
Beijng, China, 10069
Tel: 716-361-3985(8613501253203)
E-mail: [email protected]

Received Date: January 13, 2014; Accepted Date: January 25, 2014; Published Date: January 28, 2014

Citation: Dai L, Mahajan SD, Sykes DL, Shon A, Schwartz SA, et al. (2014) Prevalence of Transmitted HIV-1 Drug Resistance (TDR) Associated Mutations and Predicted Drug Sensitivity in Newly Diagnosed HIV-1 Patient Cohort in a Western New York, 2005-2011. J Antivir Antiretrovir 6:022-027. doi: 10.4172/jaa.1000090

Copyright: © 2014 Dai L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

HIV-1 drug resistance associated mutations can be transmitted to persons who are antiretroviral-naive, called Transmitted Drug Resistance (TDR). TDR has the potential to compromise first-line anti-retroviral therapy (ART) in HIV patients and limit the antiretroviral regimens options, which has become an important public health problem. TDR surveillance is an important strategy to monitor the emergence of genetic. TDR has been reported in the United States for many years. Current antiretroviral treatment guidelines recommend drug resistance testing after diagnosis. We did a retrospective analysis of the genotype database of ART-naïve patients from our immunodeficiency clinics at the Erie County Medical Center (ECMC) in Buffalo, New York, United States from 2005 to 2011. The prevalence of TDR in the ECMC-US cohort is still high 13.3%. The drug susceptibility is significantly reduced in 10.9% patients. The mutations were mostly “old” drug (such as AZT, D4T, EFV, NVP, SQV/r) related, while most of the “new” drugs (such as TDF, RPV, DRV/r) maintained sensitivity. The introduction of new second, third generation drugs in recent years has not brought down the prevalence of TDR significantly. The TDR prevalence rates in the United States are indicative of the fact that drug resistant mutations were generated before or at the beginning of ART and transmitted down from one generation to the other in ART naive patients, emphasizing that additional management strategies are needed to diagnose HIV infected patients earlier and to effectively treat them timely to further reduce TDR.

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