alexa
Reach Us +441730450007
Preventing and Reversing and#8220;Microglia-Agingand#8221; by Nature Materials for Slow Brain-Aging. J Neurol Disord 2:143. | OMICS International | Abstract
ISSN: 2329-6895

Journal of Neurological Disorders
Open Access

Our Group organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations
700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Review Article

Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging. J Neurol Disord 2:143.

Zhou Wu1#*, Aiqin Zhu2#, Shizheng Wu2 and Hiroshi Nakanishi1*

1Department of Aging Science and Pharmacology, Faculty of Dental Science, Kyushu University, Fukuoka 812-8582, Japan

2Institution of Geriatric Qinghai Provincial Hospital, Shining 810007, China

#Zhou Wu and Aiqin Zhu contributed equally to this work

Corresponding Authors:
Zhou Wu
Department of Aging Science and Pharmacology
Faculty of Dental Science, Kyushu University
Fukuoka 812-8582, Japan
Tel: 81-92-642-6412
Fax: 81-92-642-6415
E-mail: [email protected]
Hiroshi Nakanishi
Department of Aging Science and Pharmacology
Faculty of Dental Science, Kyushu University
Fukuoka 812-8582, Japan
Tel: 81-92-642-6412
Fax: 81-92-642-6415
E-mail: [email protected]

Received November 11, 2013; Accepted December 03, 2013; Published December 05, 2013

Citation: Wu Z, Zhu A, Wu S, Nakanishi H (2013) Preventing and Reversing “Microglia-Aging” by Nature Materials for Slow Brain-Aging. J Neurol Disord 2:143. doi: 10.4172/2329-6895.1000143

Copyright: © 2013 Wu Z, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

 

Abstract Mitochondrial DNA (mtDNA), which encodes components of the mitochondria electron transfer complexes, is highly susceptible to damage produced by reactive oxygen species (ROS), due to its close proximity to ROS generated through the respiratory chain and the paucity of protective histones. Accumulation of mtDNA damages during aging result in the reduced expression of the mitochondria electron transfer complexes, especially complex I. The resultant reduced activity of complex I further increases the generation of ROS, forming a vicious cycle. During aging, the accumulation of oxidative mtDNA damages is prominently found in the brain resident microglia. Increased intracellular ROS, in turn, drives microglia to provoke excessive neuroinflammation in the aged brain through activation of nuclear factor-κB (NF- κB). Hypoxia activates microglia to induce the generation of mitochondria-derived ROS and the subsequent activation of NF-κB signaling pathway to produce pro-inflammatory mediators, which impairs the cognitive functions. Propolis, a resinous substance produced by honeybees, significantly inhibits the hypoxia-induced neuroinflammatory responses by microglia. Furthermore, propolis and Ratanasampil, a traditional Tibetan medicine, improve the cognitive functions of the people who are living at high altitude. Considering that the daily exposure to hypoxia is one of risk factors for the aging-related cognitive impairments, these pharmacological approaches that prevent and reverse “microglia-aging” may become a most promising future research avenue for preventing the aging-related cognitive impairments.

Keywords

Recommended Conferences
Share This Page
Top