alexa Preventing Breast Cancer Growth by Cationic Cecropin B
ISSN: 2329-6577

Biological Systems: Open Access
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Research Article

Preventing Breast Cancer Growth by Cationic Cecropin B

Guoyao Zang1, Ashley Thomas2, Zhongyuan Liu3, Di Chen2, Hong Ling2, Liangyi Zhou2, Fuchun Zhang3, Leo Siu2 and Xiufen Zheng2,3,4*
1School of Medicine, Zhejiang University, Hangzhou, China
2Department of Surgery, Pathology, Oncology, Physiology and Pharmacology, Microbiology and Immunology, University of Western Ontario, London, Canada
3College of Biotechnology, Xinjiang University, Wulumuqi, China
4Lawson Health Research Institute, London, Canada
*Corresponding Author : Xiufen Zheng
339 Windermere Road, University Hospital B4-235
London, Ontario, N6A 5A5, Canada
Tel: 519-6636566
E-mail: xzheng26@uwo.ca
Received May 27, 2013; Accepted July 15, 2013; Published July 18, 2013
Citation: Zang G, Thomas A, Liu Z, Chen D, Ling H, et al. (2013) Preventing Breast Cancer Growth by Cationic Cecropin B. Biol Syst 2:112. doi:10.4172/2329-6577.1000112
Copyright: © 2013 Zang G, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Development of treatment resistance and lack of specificity are common problems in cancer chemotherapy, resulting in diverse and negative side effects. Emerging studies have shown that certain anti-microbial peptides (AMPs) have a destructive effect on cancer cells but no effect on normal eukaryotic cells. We isolated a cationic antimicrobial peptide--Cecropin B from silk worms infected with staphylococcus aureus and investigated its effects on breast cancer growth in vitro and in vivo. Treatment with Cecropin B induced cell death of murine breast cancer cells but not of normal nonmalignant cells. Cecropin B inhibited cancer cell proliferation as compared with control. Cecropin B treatment increased gene expression of Caspase3, Fas and high mobility group box 1 (HMGB 1). Administration of Cecropin B in vivo reduced tumor growth. In conclusion, Cecropin B possesses specific killing ability against tumor cells. There is the potential of development of anti-microbial peptides as anti-cancer drugs.

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