alexa Preventing Breast Cancer Recurrence through a Tailored Lifestyle Intervention: The MyLIFE (My Lifestyle Intervention with Food and Exercise) Trial Rationale and Study Design | Abstract
ISSN: 2167-0870

Journal of Clinical Trials
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Protocol

Preventing Breast Cancer Recurrence through a Tailored Lifestyle Intervention: The MyLIFE (My Lifestyle Intervention with Food and Exercise) Trial Rationale and Study Design

Corinne Labyak1, Karen Daily2, Laila Samiian3, Samantha A Ward4, Shannon Wallet5, Michael G Perri6, Valerie Hoover6, Linda Snetslaar7, Karla Shelnutt8, Kristin T DiGioia4, Andres Acosta9, Linda J Young10 and Anne E Mathews4*
1Department of Nutrition and Dietetics, University of North Florida, Jacksonville, FL, USA
2Division of Hematology and Oncology, Department of Medicine, University of Florida, Gainesville, FL, USA
3Department of Surgery, University of Florida-Jacksonville, Jacksonville, FL, USA
4Food Science and Human Nutrition Department, University of Florida, Gainesville, FL, USA
5Departments of Periodontology and Oral Biology, University of Florida, Gainesville, FL, USA
6Department of Clinical and Health Psychology, University of Florida, Gainesville, FL, USA
7Department of Epidemiology, University of Iowa, Iowa City, IA, USA
8Department of Family Youth and Community Sciences, University of Florida, Gainesville, FL, USA
9Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, MN, USA
10Department of Statistics, University of Florida, USA
Corresponding Author : Dr. Anne Mathews
Food Science and Human Nutrition Department
University of Florida, 359 FSHN Bldg
Newell Drive, Gainesville, FL 32611-0370, USA
Tel: 352-392-1991
Fax: 352-392-9467
E-mail: [email protected]
Received June 27, 2014; Accepted September 26, 2014; Published September 28, 2014
Citation: Labyak C, Daily K, Samiian L, Ward SA, Wallet S, et al. (2014) Preventing Breast Cancer Recurrence through a Tailored Lifestyle Intervention: The MyLIFE (My Lifestyle Intervention with Food and Exercise) Trial Rationale and Study Design. J Clin Trials 4:183. doi:10.4172/2167-0870.1000183
Copyright: © 2014 Labyak C, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Breast cancer risk, and risk of associated co-morbidities such as cardiovascular disease, is highest among overweight or obese women with a previous history of breast cancer. The objective of this study is to test the effectiveness of a tailored nutrition, physical activity, and behavioral weight management intervention for breast cancer survivors against a widely available commercial weight management program. We hypothesize that an intervention tailored to the unique psychological, nutritional, and physical needs of breast cancer survivors will provide superior physiological and psychological benefits compared to an existing commercial program for the general population. To test our hypothesis, we initially conducted a focus group with both breast cancer survivors and oncology affiliated health care providers in order to illicit feedback to develop an intervention customized specifically to breast cancer survivors. Subsequently, in a randomized, multicenter trial, we are studying the effect of the tailored program on overweight/obese women (N=120) with a history of breast cancer (3 months to 5 years post-primary treatment) on body weight and composition, markers of systemic inflammation related to cancer and associated chronic diseases, physical activity habits, dietary intake, health-related quality of life, and program adherence and satisfaction. Assessments will be taken prior to study initiation
immediately following the intervention and at 6 months post-intervention to assess long-term maintenance of weight, lifestyle behaviors, and impact on physiological markers of disease risk. This project is unique in that it addresses weight issues in a high risk, understudied population using a tailored approach.

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