alexa Prevention of Breast Cancer Could Be a Consequence of Pregnancy: A Review | OMICS International | Abstract
ISSN: 2329-9126

Journal of General Practice
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Review Article

Prevention of Breast Cancer Could Be a Consequence of Pregnancy: A Review

Jose Russo*
The Irma H. Russo MD Breast Cancer Research Laboratory, Fox Chase Cancer Center, Temple University Health System, Philadelphia, USA
Corresponding Author : Jose Russo, MD
Fox Chase Cancer Center, 333 Cottman Avenue
Philadelphia, PA 19111, USA
Tel: 215-728-4782
Fax: 215-728-2180
E-mail: [email protected]
Received May 14, 2014; Accepted June 12, 2014; Published June 16, 2014
Citation: Russo J (2014) Prevention of Breast Cancer Could Be a Consequence of Pregnancy: A Review. J Gen Pract 2:167. doi:10.4172/2329-9126.1000167
Copyright: © 2014 Russo J, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

The genomic profile of parous women has shown that genes which are activated only within the first five years after pregnancy, may contribute to the increased risk of breast cancer in certain women. At the same time, pregnancy’s protective effect is induced by a long-lasting genomic signature. This signature reveals that the differentiation process is centered around chromatin remodeling and represents a safeguard mechanism at genomic and post-transcriptional levels that maintains the fidelity of the transcription process, which could be the ultimate step mediating the protection of the breast conferred by full term pregnancy.

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