alexa Prevention of post-ERCP Pancreatitis | OMICS International | Abstract
ISSN: 2165-7092

Pancreatic Disorders & Therapy
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Review Article

Prevention of post-ERCP Pancreatitis

Takeshi Tsujino1* and Masao Omata2
1Department of Gastroenterology, Japanese Red Cross Medical Center, Japan
2Department of Gastroenterology, Yamanashi Prefectural Central Hospital, Japan
Corresponding Author : Takeshi Tsujino
Department of Gastroenterology
Japanese Red Cross Medical Center
4-1-22 Hiroo, Shibuya-ku
150-8935, Tokyo, Japan
Tel: +81-3-3400-1311
Fax: +81-3-3409-1604
E-mail: [email protected]
Received April 22, 2013; Accepted June 10, 2013; Published June 12, 2013
Citation: Tsujino T, Omata M (2013) Prevention of post-ERCP Pancreatitis. Pancreatic Dis Ther 3:123. doi:10.4172/2165-7092.1000123
Copyright: © 2013 Tsujino T, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Various factors have been shown to be associated with the development of post-ERCP pancreatitis. They are generally classified as patient-related factors and procedure-related factors. These factors exert a synergistic effect on the risk for pancreatitis after ERCP. The pathogenesis of post-ERCP pancreatitis has not been fully understood, but several factors (i.e., mechanical injury, hydrostatic injury, chemical and allergic injury, enzymatic injury, infection, and thermal injury) may act independently or in combination to provoke post-ERCP pancreatitis. Since the introduction of ERCP, numerous pharmacologic agents have been evaluated to prevent post-ERCP pancreatitis on the assumption that they pharmacologically inhibit one or more of the factors associated with pancreatic damage. Pancreatitis is the most common and feared complication of ERCP. Identification of risk factors before and during ERCP is of paramount importance. The benefit of performing ERCP should be outweighed by the risk of post-ERCP pancreatitis.

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