alexa Previous Statin Therapy Improves Clinical Outcome of Pa
ISSN: 2329-6607

Cardiovascular Pharmacology: Open Access
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Research Article

Previous Statin Therapy Improves Clinical Outcome of Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention

Kosuke Murakawa1*, Reisuke Yuyama2, Hiroshi Yokoe2, Fumio Yuasa1 and Ichiro Shiojima1

1Department of Medicine II, Kansai Medical University, Hirakata, Japan

2Department of Cardiology, Rakusai New Town Hospital, Kyoto, Japan

*Corresponding Author:
Kosuke Murakawa
Department of Medicine II
Kansai Medical University
2-5-1, Shinmachi
Hirakata, 573-1010, Japan
Tel: +81-72-804- 0101
Fax: +81-72-804-2865
E-mail: [email protected]

Received date: June 03, 2016; Accepted date: June 30, 2016; Published date: July 04, 2016

Citation: Murakawa K, Yuyama R, Yokoe H, Yuasa F, Shiojima I (2016) Previous Statin Therapy Improves Clinical Outcome of Patients with ST-Segment Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention. Cardiovasc Pharm Open Access 5:187. doi:10.4172/2329-6607.1000187

Copyright: © 2016 Murakawa K, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

Background: Statin treatment has been shown to reduce the risk of coronary artery disease and improve the outcome of patients with acute myocardial infarction. However, the effects of previous statin treatment on the clinical course of subsequent acute myocardial infarction remain unclear. This study was designed to investigate whether previous statin therapy influences the clinical outcome of patients with ST-Segment Elevation Myocardial Infarction (STEMI) treated with primary Percutaneous Coronary Intervention (PCI). Methods: We evaluated the clinical outcome of 350 patients with STEMI undergoing primary PCI, of which 91 received previous statin treatment (statin group) and 259 did not (non-statin group). Myocardial perfusion, infarct size, inflammatory responses, and Major Adverse Cardiovascular Events (MACE) were evaluated. Results: The frequency of MACE at 1 month after PCI was significantly lower in the statin group than the nonstatin group (4.4% vs. 13.9%, p=0.014). Post-PCI peak creatine kinase was significantly lower in the statin group median, (interquartile range): (1246 [504-3301] vs. 2235 [952-4083] IU/ml; p=0.002), whereas peak high-sensitivity C-reactive protein did not significantly differ between the two groups (p=0.287). The frequency of ST-segment resolution after PCI was significantly higher in the statin group (90.1% vs. 76.8%; p=0.006), as was the frequency of Thrombolysis in Myocardial Infarction grade 3 coronary flow (p=0.008). Myocardial blush grade was similar in both groups (p=0.839). Multivariate logistic regression analysis revealed previous statin treatment, hs-CRP, blood glucose, and age to be independent predictors of MACE. Conclusion: Previous statin therapy enhances coronary flow, reduces infarct size, and improves clinical outcome of STEMI patients treated with primary PCI.

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