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Rheumatoid Nodules Predating Seroconversion and Rheumatoid Arthritis: An Uncommon Case Report | OMICS International | Abstract
ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Case Report

Rheumatoid Nodules Predating Seroconversion and Rheumatoid Arthritis: An Uncommon Case Report

Roberta Gualtierotti1,2* and Francesca Ingegnoli1,2
1Division of Rheumatology, Istituto Gaetano Pini, Milan, Italy
2Department of Clinical Sciences and Community Health, University of Milan, Milan, Italy
Corresponding Author : Roberta Gualtierotti
Division of Rheumatology
Istituto Gaetano Pini
Piazza Cardinal Ferrari 1
20122 Milano, Italy
Tel: +390258296421
Fax: +390258296315
E-mail: [email protected]
Received September 21, 2013; Accepted October 21, 2013; Published October 28, 2013
Citation: Gualtierotti R, Ingegnoli F (2013) Rheumatoid Nodules Predating Seroconversion and Rheumatoid Arthritis: An Uncommon Case Report. J Clin Cell Immunol 4:167. doi:10.4172/2155-9899.1000167
Copyright: © 2013 Gualtierotti R, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Rheumatoid nodulosis is a benign condition associated with mild or no arthritis. Differently from classical rheumatoid nodules, which are relatively common in patients with long-standing rheumatoid arthritis, particularly in rheumatoid factor (RF)-positive patients, rheumatoid nodulosis may rarely precede arthritis onset and even seroconversion. We describe the clinical course of a patient with isolated painful rheumatoid nodules, who subsequently experienced RF and anti-citrullinated protein antibodies (ACPA) seroconversion and finally developed overt rheumatoid arthritis. This case should raise clinical awareness to consider rheumatoid nodulosis as a possible diagnosis even in the absence of arthritis and of RF positivity, whenever facing with isolated subcutaneous nodules.


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