Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured PreadipocytesAhmed Kablan1‡, Rudel A.Saunders1‡, Maria Szkudlarek-Mikho1, Andrew J.B. Chin1, Raul M. Bosio2, Kazuyuki Fujii1,3, Joseph Shapiro1 and Khew-Voon Chin1,4,5*
- *Corresponding Author:
- Khew-Voon Chin
Ph.D, Department of Medicine
University of Toledo, College of Medicine
Toledo, OH, United States
E-mail: [email protected]
Accepted date: September 28, 2010; Published date: September 29, 2010
Citation: Kablan A, Saunders RA, Szkudlarek-Mikho M, Chin JB, Bosio RM, et al. (2010) Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes. J Diabetes Metab 1:101. doi: 10.4172/2155-6156.1000101
Copyright: © 2010 Kablan A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
The global increase in the incidence of obesity has emerged as one of the most serious public health risks in recent years. Despite the enormity of the obesity pandemic, there are currently only two FDA-approved therapies for its treatment and these drugs exhibit modest efficacy and have limiting side effects. Prieurianin is a plant limonoid product that deters feeding in insect larvae. We investigated in this study the effects of prieurianin on weight loss and adipogenesis. Our results showed that prieurianin causes weight loss by reducing energy intake in obese mice on highcalorie diet. We also found that prieurianin is anti-adipogenic in cultured preadipocytes and adipocytes by inhibiting proliferation and differentiation of preadipocytes into adipocytes, and induces either dedifferentiation or delipidation of mature adipocytes. Whether prieurianin can potentially be used for obesity treatment in human warrants further investigation.