alexa Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes
ISSN: 2155-6156

Journal of Diabetes & Metabolism
Open Access

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Research Article

Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes

Ahmed Kablan1, Rudel A.Saunders1, Maria Szkudlarek-Mikho1, Andrew J.B. Chin1, Raul M. Bosio2, Kazuyuki Fujii1,3, Joseph Shapiro1 and Khew-Voon Chin1,4,5*

1Department of Medicine, University of Toledo, College of Medicine, Toledo, OH, United States

2Department of Surgery, University of Toledo, College of Medicine, Toledo, OH, United States

3Department of Obstetrics and Gynecology, National Defense Medical College, Tokorozawa, Saitama, Japan

4Center for Diabetes and Endocrine Research, University of Toledo, College of Medicine, Toledo, OH, United States

5Department of Biochemistry and Cancer Biology, University of Toledo, College of Medicine, Toledo, OH, United States

Department of Biochemistry and Cancer Biology, University of Toledo, College of Medicine, Toledo, OH, United States

*Corresponding Author:
Khew-Voon Chin
Ph.D, Department of Medicine
University of Toledo, College of Medicine
Toledo, OH, United States
Tel: 419-383-3502
Fax: 419-383-4473
E-mail: [email protected]

Accepted date: September 28, 2010; Published date: September 29, 2010

Citation: Kablan A, Saunders RA, Szkudlarek-Mikho M, Chin JB, Bosio RM, et al. (2010) Prieurianin Causes Weight Loss in Diet-Induced Obese Mice and Inhibits Adipogenesis in Cultured Preadipocytes. J Diabetes Metab 1:101. doi: 10.4172/2155-6156.1000101

Copyright: © 2010 Kablan A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The global increase in the incidence of obesity has emerged as one of the most serious public health risks in recent years. Despite the enormity of the obesity pandemic, there are currently only two FDA-approved therapies for its treatment and these drugs exhibit modest efficacy and have limiting side effects. Prieurianin is a plant limonoid product that deters feeding in insect larvae. We investigated in this study the effects of prieurianin on weight loss and adipogenesis. Our results showed that prieurianin causes weight loss by reducing energy intake in obese mice on highcalorie diet. We also found that prieurianin is anti-adipogenic in cultured preadipocytes and adipocytes by inhibiting proliferation and differentiation of preadipocytes into adipocytes, and induces either dedifferentiation or delipidation of mature adipocytes. Whether prieurianin can potentially be used for obesity treatment in human warrants further investigation.

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