alexa Primary Non-Hodgkin’s Lymphomas of the Uterus and Uterine Cervix
ISSN: 2471-8556

Oncology & Cancer Case Reports
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Case Report

Primary Non-Hodgkin’s Lymphomas of the Uterus and Uterine Cervix

Liza Johannesson1, Jennifer Mason1, John Miller1, Selva-Nayagam S2, and Oehler MK1,3*

1Department of Gynaecological Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

2Department of Medical Oncology, Royal Adelaide Hospital, Adelaide, South Australia, Australia

3Discipline of Obstetrics and Gynaecology, University of Adelaide, Adelaide, South Australia, Australia

*Corresponding Author:
Oehler MK
Department of Gynaecological Oncology
Royal Adelaide Hospital, North Terrace
Adelaide, SA 5000, Australia
Tel: +61883326622
E-mail: [email protected]

Received Date: January 09, 2017 Accepted Date: March 21, 2017 Published Date: March 25, 2017

Citation: Johannesson L, Mason J, Miller J, Selva-Nayagam S, Oehler MK (2017) Primary Non-Hodgkin’s Lymphomas of the Uterus and Uterine Cervix. Oncol Cancer Case Rep 3: 127. doi: 10.4172/2471-8556.1000127

Copyright: © 2017 Johannesson L, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Objective: Primary malignant non-Hodgkin’s lymphomas in the female genital tract are rare, accounting for less than 1% of all extranodal non-Hodgkin’s lymphomas.

Methods/materials: We report on four cases of primary non-Hodgkin’s lymphomas of the uterus and cervix. Three of our patients were confirmed to be diffuse large B-cell lymphomas (LBCL) and one patient to be T-cell rich LBCL on histopathological examination and immunohistochemical study. One of our three patients who presented with diffuse LBCL was diagnosed with intravascular diffuse LBCL. Other potential origins of disease were excluded.

Results: Two patients were successfully treated with chemotherapy, one with the addition of involved field radiotherapy post chemotherapy, while two had surgery followed by chemotherapy. All four patients are in complete remission with follow up period ranging from 6 months to 5 years.

Conclusions: Gynaecological lymphomas can be a diagnostic challenge due to unspecific symptoms. However, when diagnosed and treated they have a good prognosis. Clinicians should therefore include lymphoma in their differential diagnosis when investigating gynaecological symptoms.


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