alexa Primary Oral Mucosal Melanoma: a Short Review
ISSN: 2376-0427

Dermatology and Dermatologic Diseases
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Previously: Journal of Pigmentary Disorders

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Primary Oral Mucosal Melanoma: a Short Review

Hsieh Ricardo1*, Nico Marcello MS2, Claudia M. Camillo-Coutinho3, Fernandes Juliana D4, Clovis Antonio Lopes Pinto5 and Lourenço Silvia V1
1General Pathology, Dental School, University of São Paulo and Tropical Medicine Institute, University of São Paulo, Brazil
2Department of Dermatology, Medical School, University of São Paulo, Brazil
3Department of Surgical Pathology, AC Camargo Cancer Center, São Paulo, Brazil
4Department of Dermatology, Federal University of Bahia, Brazil
5Department of Surgical Pathology, AC Camargo Cancer Center, São Paulo, Brazil
Corresponding Author : Ricardo Hsieh
Faculdade de Odontologia
Universidade de São PauloAv. Prof. Lineu Prestes, 2227CEP: 05508-000, São PauloSPBrazil
Tel: 55-113-091-7895
E-mail: [email protected]
Received: March 18, 2015; Accepted: June 01, 2015; Published: June 10, 2015
Citation: Ricardo H, Nico Marcello MS, Camillo-Coutinho CM, Juliana DF, Pinto CAL, et al. (2015) Primary Oral Mucosal Melanoma: a Short Review. Pigmentary Disorders 2:192. doi:10.4172/2376-0427.1000192
Copyright: © 2015 Ricardo H, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
 

Abstract

Primary Oral Mucosal Melanoma (POMM) is a very rare entity and it develops from malignant transformation of melanocytes from mucosal epithelium. POMM has a very poor prognosis and aggressive behavior. It represents only 0.5% of all oral malignancies, accounting 0.2 to 8% of all melanomas, with an incidence of 1.2 cases per 10 million per year. POMM is asymptomatic in its early stages and usually not noticed by the patients, resulting in the delay in diagnosis. Immunoreactivity of melanoma cells to antibodies against: S-100 protein; Melan-A (MART-1) and HMB-45 (gp100) can be very useful to distinguish POMM from other malignancies. Others markers may indicate variations in its biologic behavior and prognosis, such as Ki-67; P53 and P16, and maybe useful for prognostic prediction.

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