alexa Primary Small Cell Carcinoma of Liver in a HIV/Hepatitis B Co-Infected Patient on Virologically Suppressive Antiretroviral Therapy: Case Report and Literature Review| Abstract
ISSN: 2471-8556

Oncology & Cancer Case Reports
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  • Case Report   
  • Oncology and cancer case reports 2017, Vol 3(3): 137
  • DOI: 10.4172/2471-8556.1000137

Primary Small Cell Carcinoma of Liver in a HIV/Hepatitis B Co-Infected Patient on Virologically Suppressive Antiretroviral Therapy: Case Report and Literature Review

Ameet Dravid1*, Kartik Natarajan1, Mahenderkumar Medisetty1, Vinay Thorat1, Sujit Joshi2, Mahesh Mandolkar2, Sujit Nilegaonkar2, Deepak Phalgune1, Chinmay Saraf3, Milind Kulkarni3 and Padmaj Kulkarni1,2
1Poona Hospital and Research Center, , Pune, Maharashtra, India
2Deenanath Mangeshkar Hospital, Pune, Maharashtra, , India
3Precision Diagnostics and Biosciences, , Pune, Maharashtra, India
*Corresponding Author : Ameet Dravid, Poona Hospital and Research Center, Sadashiv Peth, Pune, Maharashtra, 411004, India, Tel: 09975619766, Email: [email protected]

Received Date: Sep 29, 2017 / Accepted Date: Oct 24, 2017 / Published Date: Oct 26, 2017

Abstract

Primary small cell carcinoma of the liver is a rare tumor with few cases reported worldwide. We report a case of primary small cell carcinoma of the liver in a HIV/Hepatitis B co-infected patient on Tenofovir based virologically suppressive antiretroviral therapy (ART). Patient presented with fatigue and vomiting, two years after starting ART. CT abdomen showed hepatomegaly with diffuse infiltration. Liver biopsy established a diagnosis of small cell cancer of liver. Immunohistochemistry results were positive for synaptophysin and CD56 while they were negative for Hep par antibody stain 1. Positron Emission Tomography (PET) scan suggested a diagnosis of malignant neoplasm in the liver. Chemotherapy was started which led to hyperacute liver failure. Patient recovered from liver failure and received 3 cycles of chemotherapy. PET scan done at 3 months showed complete regression of neoplasm but prior to start of 4th cycle, neoplasm relapsed, and patient died 15 days later. Here we discuss the clinical course and treatment of a case of primary small cell carcinoma (SCC) of the liver and review the literature regarding this rare cancer

Keywords: HIV; Hepatitis B; Antiretroviral Therapy (ART); Primary small cell carcinoma of liver; Neuroendocrine tumor

Citation: Dravid A, Natarajan K, Medisetty M, Thorat V, Joshi S, et al. (2017) Primary Small Cell Carcinoma of Liver in a HIV/Hepatitis B Co-Infected Patient on Virologically Suppressive Antiretroviral Therapy: Case Report and Literature Review. Oncol Cancer Case Rep 3: 137. Doi: 10.4172/2471-8556.1000137

Copyright: © 2017 Dravid A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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