alexa Prior Light Exposure Enhances the Pupil Response to Subsequent Short Wavelength (Blue) Light
ISSN: 2155-9570

Journal of Clinical & Experimental Ophthalmology
Open Access

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Research Article

Prior Light Exposure Enhances the Pupil Response to Subsequent Short Wavelength (Blue) Light

Michael Stormly Hansen1*, Birgit Sander1, Aki Kawasaki2, Adam Elias Brøndsted1,Claus Nissen1 and Henrik Lund-Andersen1
1Department of Ophthalmology, Glostrup Hospital, University of Copenhagen, Denmark
2Department of Neuro-Ophthalmology, Hôpital Ophtalmique Jules Gonin and University Eye Clinics of Lausanne, Lausanne, Switzerland
Corresponding Author : Michael Stormly Hansen
Glostrup Hospital
Department of Ophthalmology Nordre Ringvej 57
DK-2600 Glostrup, Denmark
Tel: 45-3863- 4825
Fax: 45-3863-4666
E-mail: [email protected]
Received January 08, 2011; Accepted April 05, 2011; Published April 07, 2011
Citation: Hansen MS, Sander B, Kawasaki A, Brøndsted AE, Nissen C, et al. (2011) Prior Light Exposure Enhances the Pupil Response to Subsequent Short Wavelength (Blue) Light. J Clinic Experiment Ophthalmol 2:152. doi:10.4172/2155-9570.1000152
Copyright: © 2011 Hansen MS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Background and Purpose: The photo pigment melanopsin initiates cell depolarization in response to highintensity, short-wavelength light. Antecedent long-wavelength light may potentiate regeneration of the melanopsin photo pigment, We investigated the influence of red or blue exposure on the pupil response to subsequent blue light.
 
Methods: Nine healthy subjects were examined using chromatic pupillometry. With a sequence of 3 consecutive blue exposures or a sequence in which the middle exposure was red light, both sequences repeated in the darkadapted state. The summed pupil response during light was obtained as the area under the curve and the percentage difference (diff %) between the first and last blue stimulus was calculated for each sequence.
 
Findings: The pupil response to the third blue exposure was greater than to first blue light. No significant difference was seen in the diff% when comparing a sequence with a blue intervening versus red intervening light, in the light adapted (P = 0.39) or dark adapted state (P = 0.58).
 
Conclusion: Prior light exposure enhances the pupil response to subsequent blue light stimulation, no differential effect was found between blue and red light. This study suggests that antecedent light history is important when designing protocols and evaluating results of chromatic pupillometry.
 

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