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ISSN: 2155-9899

Journal of Clinical & Cellular Immunology
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Review Article

Pro- and Anti-inflammatory Neutrophils in Lupus

Evan Der, Abhishek Trigunaite, Ayesha Khan and Trine N. Jørgensen*
Department of Immunology, Lerner Research Institute, Cleveland Clinic Foundation, Ohio, USA
Corresponding Author : Dr. Trine N. Jørgensen
Department of Immunology, NE40 Lerner Research Institute
Cleveland Clinic Foundation, Ohio, USA
Tel: +1 216-444-7454
Fax: +1 216-444-9329
E-mail: [email protected]
Received April 14, 2014; Accepted July 09, 2014; Published July 16, 2014
Citation: Der E, Trigunaite A, Khan A, Jørgensen TN (2014) Pro- and Anti-inflammatory Neutrophils in Lupus. J Clin Cell Immunol 5:239. doi: 10.4172/2155-9899.1000239
Copyright: © 2014 Der E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

A hallmark of SLE is the presence of elevated levels of circulating anti-nuclear autoantibodies specific towards chromatin, histones or dsDNA. Understanding the regulation of antibody production is therefore of utmost importance in understanding lupus pathogenesis. Spearheaded by the identification of accumulating immunosuppressive neutrophils in cancer patients, the nature and function of neutrophils have expanded from a uniform pro-inflammatory cell population to a heterogeneous population of cells with pro-inflammatory or immunosuppressive capacities. While much is known about pro-inflammatory neutrophils and the likely pathogenic function of such cells in lupus, a potential role for immunosuppressive neutrophils in protecting genetically predisposed individuals has only recently emerged. For example, SLE-derived neutrophils spontaneously produce type I interferons (IFNα), strongly associated with disease development, release chromatin-containing neutrophil extracellular traps (NETs), potentially functioning as a source of nuclear auto-antigen, and may activate B cells in a T cell independent fashion. In contrast, levels and functions of regulatory neutrophils (Nregs) involved in T celldependent B cell differentiation and germinal center reactions, are dysregulated in female lupus-prone mice during disease development. Here we review data supporting a role for both pro- and anti-inflammatory neutrophils in lupus.

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