alexa Probe-Based Confocal Laser Endomicroscopy of the Lungs
ISSN: 2161-105X

Journal of Pulmonary & Respiratory Medicine
Open Access

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Review Article

Probe-Based Confocal Laser Endomicroscopy of the Lungs

Meng Peng1, Tan Gan Liang2 and Devanand Anantham1,2*

1Duke-NUS Graduate Medical School, Singapore

2Department of Respiratory and Critical Care Medicine, Singapore General Hospital, Singapore

*Corresponding Author:
Devanand Anantham
Department of Respiratory and Critical Care Medicine
Academia Building Level 3, Singapore General Hospital
Outram Road-169608, Singapore
Tel: 65-63214700
Fax: 65-62271736
E-mail: [email protected]

Received date: July 23, 2015; Accepted date: October 19, 2016; Published date: October 22, 2016

Citation: Peng M, Liang TG, Anantham D (2016) Probe-Based Confocal Laser Endomicroscopy of the Lungs. J Pulm Respir Med 6:373. doi: 10.4172/2161-105X.1000373

Copyright: © 2016 Peng M, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Probe-based confocal laser endomicroscopy (pCLE) is a relatively new technology in pulmonary medicine. Real time, in vivo visualization of elastin microstructure in the airway wall as well as alveoli is possible via flexible bronchoscopy under moderate sedation. This technique delivers high quality images without significant morbidity, and potentially enables non-invasive diagnosis. The images acquired have low intraobserver and intrapatient variability. The structure or normal airways and alveoli have already been elucidated. pCLE has been used in pilot studies for the diagnosis of various malignant lesions, airway diseases and diffuse parenchymal lung diseases. There may also be a role in monitoring of treatment response and disease progression. However, development is still needed both in the technology and standardization of endoscopic procedure to realize the full potential of pCLE.


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