Probiotic Potential of Lactobacillus Strains on the Adipogenesis of 3T3-L1 Cells
Received Date: Aug 04, 2018 / Accepted Date: Dec 11, 2018 / Published Date: Dec 19, 2018
Obesity is the most common health problem in developed countries and is considered a significant risk factor for many major human diseases. This study aimed to evaluate the inhibitory effect of lactic acid bacteria isolated from the human vagina on adipocyte differentiation in 3T3-L1 preadipocytes. We screened 26 strains of lactic acid bacteria to test their effects against obesity. Among the tested strains, Lactobacillus gasseri MG2855 exhibited a lipase inhibitory activity of 11.84% and inhibited relative lipid content of 3T3-L1 cells (96.21%) at a concentration of 1,000 μg/mL. The survival rate of L. gasseri MG2855 in 0.3% bile salt was 88.47%, and the survival rate after incubation for 3 h in pH 3.0 was 78.64%. L. gasseri MG2855 showed higher sensitivity to erythromycin, chloramphenicol, tetracyclin, and cephalothin in 16 antibiotic sensitivity tests. These results demonstrate that L. gasseri MG2855 can be employed as a potential probiotic with anti-obesity effects.
Keywords: Lactic acid bacteria; Antiobesity; Probiotic; Lactobacillus gasseri
Citation: Kang CH, So JS, Han SH, Kim YG, Jeong Y, et al. (2018) Probiotic Potential of Lactobacillus Strains on the Adipogenesis of 3T3-L1 Cells. J Food Ind Microbiol 4: 124. Doi: 10.4172/2572-4134.1000124
Copyright: © 2018 Kang CH, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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