Progesterone for Prevention of Recurrent Preterm Labor after Arrested Preterm Labor- A Randomized Controlled Trial
Mohan C. Regmi*, Pappu Rijal, Ajay Agrawal and Dhruba Uprety
Department of Obstetrics and Gynecology, BPKIHS, Dharan, Nepal
- Corresponding Author:
- Mohan C. Regmi
Associate Professor, Department of Obstetrics and Gynecology
BPKIHS, Dharan, Nepal
E-mail: [email protected]
Received Date: June 17, 2012; Accepted Date: July 11, 2012; Published Date: July 17, 2012
Citation: Regmi MC, Rijal P, Agrawal A, Uprety D (2012) Progesterone for Prevention of Recurrent Preterm Labor after Arrested Preterm Labor- A Randomized Controlled Trial. Gynecol Obstet 2:125. doi: 10.4172/2161-0932.1000125
Copyright: © 2012 Regmi MC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Background: Preterm birth is the major cause of neonatal mortality and morbidity. In developing countries, it’s a major health hazard. But there are very few evidence based interventions to prevent it. This study focus on prevention of preterm birth.
Methods: A randomized controlled trial was undertaken in BP Koirala Institute of Health Sciences, where 60 patients were randomized into group 1 (n=29, weekly intramuscular Progesterone) and group 2 (n=31,no treatment) after the arrest of preterm labor with tocolysis. Their latency period till delivery and recurrence of preterm labor and neonatal outcomes were compared.
Results: There was significant reduction in recurrence of preterm labor and increase in latency period in progesterone group. However neonatal outcomes were similar.
Conclusion: Progesterone is useful in reducing the recurrence of preterm labor in a patient who had preterm labor.