Progestins/Antiprogestins: Role in Pathogenesis and Treatment for EndometriosisShylesh S. Bhaskaran and Hareesh B. Nair*
Southwest National Primate Research Center, Texas Biomedical Research Institute, San Antonio TX 78227, USA
- *Corresponding Author:
- Hareesh B. Nair
Southwest National Primate Research Center
Texas Biomedical Research Institute
7620 NW Loop 410
San Antonio TX 78227, USA
E-mail: [email protected]
Received date: May 29, 2012; Accepted date: May 29, 2012; Published date: May 31, 2012
Citation: Bhaskaran SS, Nair HB (2012) Progestins/Antiprogestins: Role in Pathogenesis and Treatment for Endometriosis. Gynecol Obstet 2:e105. doi: 10.4172/2161-0932.1000e105
Copyright: © 2012 Bhaskaran SS, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Endometriosis is a painful gynecological condition in the fertile-age in which presence of endometrial tissue develops outside the uterus, which under normal situation found only in the inside lining of the uterus, attach to pelvic floor, endometrium or peritoneal cavity. Endometriosis cause abdominal pain, bleeding, irregular menstrual cycles with excessive pain, inflammatory responses and infertility. Retrogressive menstruation and invasion theories have been well studied in the pathogenesis of endometriosis. Role of steroids including estrogen, gonadotropin releasing hormones has been documented and major treatment strategies are based on steroid biology of endometriosis. Current treatment strategies are less successful and solely focusing on the late phase of the disease. The exact role of progesterone in the initiation (initial phase) of endometriosis has not been well studied or overshadowed by the concept of progesterone resistance that occurs in late phase in endometriosis. In this review, we are discussing the role of progesterone and potential use of anitprogestins or possible combination treatment strategies which may help to combat initiation and progression of endometriosis.