Prognostic Factors Including Clinical Manifestation and Paraclinic Finding in Sever Methanol Toxicity
- *Corresponding Author:
- Dr. Pajoumand Abdolkarim
Toxicological Research Center
Loghman Hakim Hospital
Shahid Beheshti University of Medical Sciences, Tehran, Iran
E-mail: [email protected]
Received date: June 19, 2013; Accepted date: July 23, 2013; Published date: July 25, 2013
Citation: Abdolkarim P (2013) Prognostic Factors Including Clinical Manifestation and Paraclinic Finding in Sever Methanol Toxicity. J Alcoholism Drug Depend 1:125. doi:10.4172/2329-6488.1000125
Copyright: © 2013 Abdolkarim P. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: Ingested methanol (a toxic alcohol) undergoes enzymatic oxidation to toxic formic acid, resulting in acidosis and formaldehyde which resulted in neurotoxicity specifically optic neuritis and blindness and death in severe poisoning. According to Iranian law, selling, buying and consumption of alcoholic beverages is a punishable crime and people who wish to drink alcohol use industrial or homemade ethanol. Due to depressant effects of methanol on the central nervous system, the objective of this study was to assess the pathologic findings on brain CT scan in methanol poisoned patients beside of their clinical information.
Material and method: This prospective study was from Jan 2013 to May 2013. All 20 methanol poisoned patients examined and questionnaires were filled by physician. Brain CT scans without contrast medium were obtained.
Results: All of cases were male; their mean age was 33.1 ± 9.2 years. The mortality rate was 15%. Hemodialysis was performed in 85% cases. Mean primary Methanol Level was 22.4 ± 10.5 mg/dL and after hemodialysis was 7.3 ± 6.1. Totally serum methanol levels pre and post hemodialysis were 22.4 and 7.3, respectively. Brain death was recorded in 2 patients. The most common findings at admission were loss of consciousness (n=11) and blurred vision (n=9). The early pathologic brain CT findings were bilateral hypo density lesion in putamen, low attenuation in sub cortical, white matter bilateral hemorrhagic necrosis in putamen and bilateral hypo density in globuspallidus, respectively.
Conclusion: In conclusion, it seems CT finding are important as Methanol concentration before any other Para clinic findings and even clinical manifestations.