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Prognostic Value of Cell Cycle Proteins in Squamous Cell Carcinomas of the Oral Cavity | OMICS International | Abstract

Journal of Molecular Biomarkers & Diagnosis
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Research Article

Prognostic Value of Cell Cycle Proteins in Squamous Cell Carcinomas of the Oral Cavity

Marcilei Eliza Cavicchioli Buim1*, José Humberto Fregnani2, Silvia Vanessa Lourenço3, Cibele Pidorodeski Nagano3, André Lopes Carvalho4 and Fernando Augusto Soares1

1Department of Anatomical Pathology, Hospital A.C. Camargo, São Paulo, Brazil

2Center for Researcher Support, Hospital de Câncer de Barretos, Barretos, Brazil

3Department of General Pathology, Dental School, University of São Paulo, Brazil

4Department of Head and Neck Surgery, Hospital de Câncer de Barretos, Barretos, Brazil

*Corresponding Author:
Marcilei EC Buim, PhD
Hospital A.C. Camargo
Department of Anatomical Pathology
123 Artur Prado st, Zip Code 01322-000
São Paulo- Brazil
Phone/Fax: +55 11 21895185
E-mail: [email protected]

Received Date: May 23, 2011; Accepted Date: August 01, 2011; Published Date: August 07, 2011

Citation: Buim MEC, Fregnani JH, Lourenço SV, Nagano CP, Carvalho AL (2011) Prognostic Value of Cell Cycle Proteins in Squamous Cell Carcinomas of the Oral Cavity. J Mol Biomark Diagn 2:111. doi:10.4172/2155-9929.1000111

Copyright: © 2011 Buim MEC, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited


The cell cycle is under strict regulation. Cyclin-dependent kinases (CDKs) at the G1-S and G2-M checkpoints are positively regulated by cyclins and negatively regulated by CDK inhibitors. Oral squamous cell carcinoma (OSCC) is a common malignancy that is characterized by a high degree of local aggression and lymph node metastasis. We examined positive regulators of the cell cycle (cyclin A, cyclin B1, and cyclin D1), cell cycle inhibitors (p16, p21, p27, p53, and Rb), and the proliferation markers Ki-67 and topoisomerase IIA by immunohistochemistry in a tissue microarray, comprising 136 cases of OSCC. Expression of cyclin A, cyclin B1, cyclin D1, topoisomerase IIA, p53, and Rb was positively associated with Ki-67. Overexpression of cyclin D1 correlated with the presence of lymph node metastasis. Overexpression of cyclin A, cyclin D1, topoisomerase IIA, and Rb and downregulation of p21 and p27 were associated with reduced overall survival in OSCC patients. Cyclin A, p21 and p27, were implicated an independent prognostic factor, by multivariate analysis, in OSCC patients. In conclusion, cyclin A, cyclin D1, p21 and p27 expression can be a valuable marker of poor prognosis and tumor aggressiveness in OSCC.


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