Prognostic Value of Proinflammatory Cytokines in Breast CancerAhmed A. Al-Hassan1, Batool H. Al-Ghurabi2 and Isam Hussain Al-Karkhi2*
- *Corresponding Author:
- Isam Hussain Al-Karkhi
Department of Basic Science
College of Dentistry
University of Baghdad, Baghdad, Iraq
E-mail: [email protected]
Received date:October 25, 2012; Accepted date:November 12, 2012; Published date: November 16, 2012
Citation: Al-Hassan AA, Al-Ghurabi BH, Al-Karkhi IH (2012) Prognostic Value of Proinflammatory Cytokines in Breast Cancer. J Biomol Res Ther 1:104. doi: 10.4172/2167-7956.1000104
Copyright: © 2012 Al-Hassan AA, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Cytokines are factors that are known to have both tumor-promoting and inhibitory effects on breast cancer growth. Different cytokines play an important role in controlling the immune system. This study was carried out to investigate the alterations in serum levels of proinflammatory cytokines (IL-1α, IL-6 and TNF-α) in breast cancer patients, and its relation with progression of this cancer. The current results revealed that there is significant elevation in median serum levels of IL-1α, IL-6 and TNF-α, P<0.001 in breast cancer patients, as compared with control groups, this elevation was significantly associated with advanced stage, P<0.001. These finding suggest that serum levels of IL-1α, IL-6 and TNF-α appears to be of some prognostic value in breast cancer.