Prognostication of Histomorphological Characteristics in Multiple Myeloma
- *Corresponding Author:
- Dr. Erukkambattu Jayashankar, MD
Kamineni Hospitals Limited,
E-mail: [email protected]
Received Date: July 16, 2010; Accepted Date: August 24, 2010; Published Date: August 24, 2010
Citation: Jayashankar E, Roshinipaul T (2010) Prognostication of Histomorphological Characteristics in Multiple Myeloma. J Cancer Sci Ther 2: 153- 156. doi:10.4172/1948-5956.1000041
Copyright: © 2010 Jayashankar E, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Objective: To study the utility of Bartl ÃÂs histological grade and staging in the prognostication of multiple myeloma.Methods: It was both a retrospective and prospective study done using all the cases of multiple myeloma from January 2001 to December 2002 with 2 years follow up. These cases were studied with special reference to Plasma cell morphology, biopsy growth pattern and tumor burden. In addition the effects of chemotherapy on post therapy marrow were also studied.
Results: During this period we studied 40 cases, of which 34 cases were Marschalko type, 6 cases Plasmablastic. The volume of infi ltration, 29 cases showed > 50% of volume of infi ltration, 3 cases showed 20-50% of volume of infi ltration and 8 cases showed <20% of volume of infi ltration. In the Pattern of involvement, Interstitial+Nodular type of involvement was commonly noted in 18 cases, interstitial type was seen in 15 cases and diffuse type was observed in 7 cases.
Conclusion: Bone marrow aspiration along with trephine biopsy is essential for the diagnosis and management of multiple myeloma.