alexa Progress in HIV-Carbohydrate Interactions: Infectivity of CCR5-Tropic HIV-1 is Enhanced by GP120 from CXCR4-Tropic Virus
ISSN: 2168-958X

Journal of Glycobiology
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Progress in HIV-Carbohydrate Interactions: Infectivity of CCR5-Tropic HIV-1 is Enhanced by GP120 from CXCR4-Tropic Virus

Schwalbe B, Hauser H and Schreiber M*
Bernhard Nocht Institute for Tropical Medicine, Department of Virology, Germany
*Corresponding Author : Schreiber M
Bernhard Nocht Institute for Tropical Medicine
Department of Virology, Germany
Tel: +49 40 42818461
E-mail: [email protected]
Received August 18, 2014; Accepted August 30, 2014; Published September 01, 2014
Citation: Schwalbe B, Hauser H, Schreiber M (2014) Progress in HIV-Carbohydrate Interactions: Infectivity of CCR5-Tropic HIV-1 is Enhanced by GP120 from CXCR4-Tropic Virus. J Glycobiol 3:110. doi:10.4172/2168-958X.1000110
Copyright: © 2014 Schwalbe B, et al., This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.


Human immunodeficiency virus type-1 is highly variable and utilizes two independent pathways, one via the CCR5 coreceptor and the other via CXCR4 to enter CD4+ cells. Both virus types can simultaneously be found in HIV-1-infected patients and the shift to a majority of CXCR4-tropic viruses is an indication for the development of AIDS-related symptoms. It is thought that each virus type will infect cells independently using its specific coreceptor pathways. In this short communication we demonstrate that CCR5-tropic HIV-1 is enhanced by the envelope from CXCR4-tropic viruses. This cross-enhancing effect was completely suppressed when the target cells were pretreated with hexadimethrine bromide, suggesting that carbohydrate structures on the cellular membrane play an important role for envelope-dependent enhancement of viral entry.


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