alexa Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research
ISSN: 2329-6577

Biological Systems: Open Access
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Review Article

Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research

Andréia Patrícia Gomes1,5*, Paulo Sérgio Balbino Miguel1, Débora Letícia Souza Alves1, Victor H Inoue2, Alcione de Paiva Oliveira2, Fábio R Cerqueira2, Túlio César Correia Lopes1, Luiz Alberto Santana1,5, Mauro Geller3 and Rodrigo Siqueira-Batista1,4,6

1Departamento de Medicina e Enfermagem, Universidade Federal de Viçosa UFV–Viçosa (MG), Brazil

2Departamento de Informática, Universidade Federal de Viçosa, UFV–Viçosa (MG), Brazil

3Faculty of Medicine, New York University – NYU, New York, USA

4Programa de Pós-graduação em Bioética, Ética Aplicada e Saúde Coletiva Universidade Federal do Rio de Janeiro, UFRJ - Rio de Janeiro, RJ, Brazil

5Programa de Pós- graduação em Ciências da Saúde, UFV–Viçosa (MG), Brazil

6Núcleo de Estudos em Ciências Médicas, Faculdade Dinâmica do Vale do Piranga, FADIP - Ponte Nova (MG), Brasil

Corresponding Author:
Andréia Patrícia Gomes
Departamento de Medicina e Enfermagem
Universidade Federal de Viçosa, Avenida P. H. Rolfs
s/n, Campus Universitário, CEP: 36571-000 - Viçosa (MG), Brazil
Tel: (31) 3899-3978
E-mail: [email protected]

Received Date: April 18, 2016; Accepted Date: May 26, 2016; Published Date: June 02, 2016

Citation: Gomes AP, Miguel PSB, Alves DLS, Inoue VH, de Paiva Oliveira A, et al. (2016) Pro-Inflammatory Cytokines in Sepsis: Biological Studies and Prospects From In Silico Research. Biol Syst Open Access 5:158. doi:10.4172/2329-6577.1000158

Copyright: © 2016 Gomes AP, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.



Sepsis is one of the leading causes of death in intensive care units (ICUs) and is responsible for thousands of annual deaths worldwide. The pro-inflammatory cytokines are necessary for the control of infection and are the primary focus of this paper. Due to their central role in the pathogenesis of sepsis, more emphasis is needed on the use of cytokine as biomarkers. Implementation of the cytokines in the AutoSimmune for immune system simulations may improve understanding of aspects of the physiopathology of disease in humans. We present the principal aspects of the pathogenesis of the pro-inflammatory response in sepsis and the possibilities of their modulation in order to alter the course of this illness. We highlight the main pro-inflammatory cytokines that may be used as biomarkers in clinical practice. We also discuss the perspectives of sepsis in silico investigation, using the AutoSimmune computational system. Sepsis remains a true challenge in contemporary clinical practice, especially in terms of diagnosis, therapeutics, and prognosis. A greater understanding of inflammation in sepsis – especially in relation to cellular and molecular participation in the development of the morbid process – has the potentiality for the development of new investigative methods and outcome prediction, elements that may aid in offering good patient care.

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