Role of Zinc in Shaping the Gut Microbiome; Proposed Mechanisms and Evidence from the Literature
Received Date: Jan 09, 2018 / Accepted Date: Jan 16, 2018 / Published Date: Jan 23, 2018
Abstract
Zinc is an important constituent of diet that regulates gut epithelial wall and modify gut microbiome in humans as well as animals. Zinc deficiency may affect 39% children in Pakistan, according to the recent National Nutritional Survey 2011. Although zinc has been used in the prevention and treatment of diarrhea, the relationship of plasma zinc status with potentially pathogenic bacteria has not been studied. In this review, we have discussed evidence suggesting the impact of zinc on gut microbiota and its interaction with gut epithelium. Furthermore, animal and human studies suggesting the role of zinc in modifying gut microbiota have been presented.
Keywords: Zinc deficiency; Gut microbiome; Gut epithelium
Citation: Usama U, Khan MJ, Fatima S (2018) Role of Zinc in Shaping the Gut Microbiome; Proposed Mechanisms and Evidence from the Literature. J Gastrointest Dig Syst 8: 548. Doi: 10.4172/2161-069X.1000548
Copyright: © 2018 Usama U, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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