alexa Proline-Directed Androgen Receptor Phosphorylation
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
Open Access

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Review Article

Proline-Directed Androgen Receptor Phosphorylation

Yanfei Gao and Shaoyong Chen*

Division of Hematology/Oncology, Beth Israel Deaconess Medical Center, Harvard Medical School 330 Brookline, MA 02115, USA

*Corresponding Author:
Shaoyong Chen
Division of Hematology/Oncology
Beth Israel Deaconess Medical Center
Harvard Medical School
330 Brookline, MA 02115, USA
Tel: 001-617-735-2030
Fax: 001-617-735-2844
E-mail: [email protected]

Received date: July 30, 2013; Accepted date: August 23, 2013; Published date: August 26, 2013

Citation: Gao Y, Chen S (2013) Proline-Directed Androgen Receptor Phosphorylation. J Mol Genet Med 7:075. doi: 10.4172/1747-0862.1000075

Copyright: © 2013 Gao Y, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited

 

Abstract

The androgen receptor (AR) has been identified for decades and mediates essential steroid functions. Like most of biological molecules, AR functional activities are modulated by post-translational modifications. This review is focused on the reported activities and significance of AR phosphorylation, with particular emphasis on prolinedirected serine/threonine phosphorylation that occurs predominantly on the receptor. The marked enrichment of AR phosphorylation in the most diverse N-terminal domain suggests that targeting AR phosphorylation can be synergistic to antagonizing the C-terminal domain by clinical antiandrogens.

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