alexa Prolonged Blood Circulation Time of Antimony in Dogs wi
ISSN: 2155-983X

Journal of Nanomedicine & Biotherapeutic Discovery
Open Access

Like us on:
OMICS International organises 3000+ Global Conferenceseries Events every year across USA, Europe & Asia with support from 1000 more scientific Societies and Publishes 700+ Open Access Journals which contains over 50000 eminent personalities, reputed scientists as editorial board members.

Open Access Journals gaining more Readers and Citations

700 Journals and 15,000,000 Readers Each Journal is getting 25,000+ Readers

This Readership is 10 times more when compared to other Subscription Journals (Source: Google Analytics)

Research Article

Prolonged Blood Circulation Time of Antimony in Dogs with Visceral Leishmaniasis from Liposomes with 175-nm Diameter

Erly Guilherme Azevedo1, Raul Rio Ribeiro2, Cláudio dos Santos Ferreira3, Sydnei Magno da Silva4, Dante Aligheiri Schettini5, Marilene Suzan Marques Michalick4, Cynthia Demicheli6 and Frédéric Frézard1*

1Department of Physiology and Biophysics, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil

2Department of Veterinary Medicine, Center for Agricultural Sciences, Environmental and Biological Sciences, Federal University of Bahia Recôncavo, Campus of Cruz das Almas, Centre, 44380-000 Cruz das Almas, Bahia, Brazil

3Instituto of Exact Sciences and Technology, Forest Campus, University of Viçosa, LMG 818 km Highway 06, Forest 35690-000, MG, Brazil

4Departament of Parasitology, Institute of Biological Sciences, Federal University of Minas Gerais, Av Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil

5D. West Campus Center Lindu, Federal University of Sao Joao del Rei, Av Sebastian 400 Gonçalves Coelho, Chanadour, Divinópolis 35501-296, MG, Brazil

6Department of Chemistry, Institute of Exact Sciences, Federal University of Minas, Gerais, Av Antonio Carlos 6627, Pampulha, 31270-901 Belo Horizonte, MG, Brazil

*Corresponding Author:
Frédéric Frézard
Department of Physiology and Biophysics
Institute of Biological Sciences
Federal University of Minas Gerais, Av Antonio Carlos 6627
Pampulha, 31270-901 Belo Horizonte, MG, Brazil.
Tel :
+55 31 34092940
Fax: +55 31 34092924
E-mail: [email protected]

Received date: November 21, 2011; Accepted date: December 08, 2011; Published date: December 13, 2011

Citation: Azevedo EG, Ribeiro RR, Ferreira CS, da Silva SM, Schettini DA, et al. (2011) Prolonged Blood Circulation Time of Antimony in Dogs with Visceral Leishmaniasis from Liposomes with 175-nm Diameter. J Nanomedic Biotherapeu Discover 1:101. doi:10.4172/2155-983X.1000101

Copyright: © 2011 Azevedo EG, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

 

Abstract

The achievement of parasitological cure of dogs with visceral Leishmaniasis (VL) remains a great challenge, since dogs act as main reservoir for transmission of Leishmania infantum to humans and respond poorly to conventional drugs including pentavalent antimonials. Liposome-encapsulated antimonials are hundreds of times more effective than the free drugs against VL based on parasite suppression in the liver. However, complete parasite elimination in dogs seems to depend on the ability of liposomes to reach less accessible infection sites such as the bone marrow and the skin. Recently, the reduction of liposome size from 1200- to 400-nm diameter was found to improve the targeting of Sb to the bone marrow of dogs with VL. In the present work, the influence of further reduction of vesicle diameter from 400- to 175-nm on the pharmacokinetics of Sb in dogs with VL and on the distribution of Sb in the liver, spleen and bone marrow were investigated. For this purpose, two liposome formulations of meglumine antimoniate with the same lipid composition but different mean hydrodynamic diameters were prepared. The formulations were given to mongrel dogs with VL as a single intravenous bolus injection and Sb concentrations were determined by graphite furnace atomic absorption spectroscopy. Surprisingly, much more prolonged blood levels of Sb were achieved from small size (175 nm) than medium size (400 nm) liposomes. Small size vesicles were also less effective than medium size ones in targeting Sb to the liver. On the other hand, similar Sb concentrations were achieved in both spleen and bone marrow. In conclusion, the prolonged blood circulation time of liposomes with 175-nm diameter makes this nanosystem suitable for passive drug targeting to the less accessible infection sites in dogs with VL.

Keywords

Share This Page

Additional Info

Loading
Loading Please wait..
 
Peer Reviewed Journals
 
Make the best use of Scientific Research and information from our 700 + peer reviewed, Open Access Journals
International Conferences 2017-18
 
Meet Inspiring Speakers and Experts at our 3000+ Global Annual Meetings

Contact Us

 
© 2008-2017 OMICS International - Open Access Publisher. Best viewed in Mozilla Firefox | Google Chrome | Above IE 7.0 version
adwords