alexa Prolonged Immunodeficiency in a Patient with Burkitt's Lymphoma after Treatment with Rituximab and Chemotherapy
ISSN: 1747-0862

Journal of Molecular and Genetic Medicine
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Case Report

Prolonged Immunodeficiency in a Patient with Burkitt's Lymphoma after Treatment with Rituximab and Chemotherapy

Arjun Adapa1 and Sudhir Sekhsaria2*

1University of Maryland, College Park, MD, USA

2MedStar Union Memorial Hospital, Baltimore, MD, USA

Corresponding Author:
Sudhir Sekhsaria, MD
MedStar Union Memorial Hospital
3333 N. Calvert Street Suite 520
Baltimore, MD 21218, USA
Tel: 4105546516
Fax: 4105546517
E-mail: [email protected]

Received date: January 27, 2015; Accepted date: March 03, 2015; Published date: March 10, 2015

Citation: Adapa A, Sekhsaria S (2015) Prolonged Immunodeficiency in a Patient with Burkitt’s Lymphoma after Treatment with Rituximab and Chemotherapy. J Mol Genet Med 9:165. doi:10.4172/1747-0862.1000165

Copyright: © 2015 Adapa A, et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

Abstract

Common-variable immunodeficiency (CVID) is a heterogeneous disorder characterized by recurrent bacterial infections, hypogammaglobulinemia, and impaired antibody responses. Patients with CVID can remain undiagnosed for many years but carry an increased risk for developing B cell derived non-Hodgkin’s lymphomas, such as Burkitt’s lymphoma. Screening for CVID in patients diagnosed with Burkitt’s lymphoma is necessary before prescribing treatments, because certain regimens may significantly increase the risk for flare-up of CVID that could result in prolonged immunodeficiency. We present a patient who was diagnosed with Burkitt’s lymphoma and sustained prolonged severe immunodeficiency after receiving a complete course of rituximab and chemotherapy treatment. This case report illustrates the need for an immunological work-up in lymphoma patients before initiation of treatment because of the increased incidence of lymphoma in patients with immunodeficiencies. Patients with lymphoma should also be monitored longitudinally for immunodeficiencies after treatment with rituximab with or without chemotherapy.

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