alexa Promastigote Existence in Infected Lesions of Cutaneous
ISSN: 2329-9126

Journal of General Practice
Open Access

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Review Article

Promastigote Existence in Infected Lesions of Cutaneous Leishmaniasis

Mohammed Wael Daboul*
Daboul Medical Laboratory, Damascus University, Syria, Saudi Arabia
Corresponding Author : Mohammed Wael Daboul
Doctor in Dentistry
Daboul Medical Laboratory
Damascus University, Syria, Saudi Arabia
Tel: 0096311 3349950
E-mail: [email protected]
Received September 9, 2014; Accepted October 15, 2014; Published October 28, 2014
Citation: Daboul MW (2014) Promastigote Existence in Infected Lesions of Cutaneous Leishmaniasis. J Gen Practice 2:183. doi: 10.4172/2329-9126.1000183
Copyright: © 2014 Daboul MW. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Abstract

Leishmaniasis is an endemic parasitic disease in 88 countries. It is widely distributed throughout the world, caused by vector-borne, obligate, intracellular hemoflagellates of the genus leishmania. The parasite continues its life cycle transforming to promastigote in the midgut of the sandfly vector and is transmitted to the human host in the form of promastigote through the bite of the sandfly. Other less encountered forms of transmissionare because of a laboratory accident, direct person-to-person transmission, organ transplant and blood transfusion. There is evidence that leishmaniasis may be transmitted either in utero or during the peripartum period. The promastigote form is considered the primary organism of disease transmission between the vector and the host. By not having a chance to continue its life cycle and transform into promastigote within the vector sandfly, and considering the many different routes of transmission other than the sandfly bites, it is reasonable to assume an alternative possible existence of the promastigote form of the parasite in the infected lesion of cutaneous leishmaniasis in human host. The information presented below indicates that a real transformation of amastigote to promastigote form occurs within the human host cutaneous lesion in the extracellular fluid after the macrophage membrane eruption and the amastigote release. New techniques are recommended for future studies to confirm these findings including realtime Polymerase chain reaction (PCR) and applying the immunohistochemistry techniques using novel monoclonal antibody (mAb) against the parasite flagellate (promastigote form) cell wall component.

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